Scientists at Case Western Reserve University School of Medicine have identified a novel mechanism that could be used to protect the brain from damage due to stroke and a variety of neurodegenerative conditions, including sporadic Creutzfeldt-Jakob disease, Alzheimer's disease, and Parkinson's disease.

Neena Singh, MD, PhD, a professor of pathology at the school, has spent much of her career studying the role of metals such as iron, copper, and zinc in the pathology of neurodegenerative diseases. She has previously reported that some of these metals are regulated by the brain's normal prion protein, called PrPC. Her goal is to identify common pathogenic processes in neurodegenerative diseases that could lead to the development of a new generation of treatments.

Records of Spanish shipwrecks combined with tree-ring records show the period 1645 to 1715 had the fewest Caribbean hurricanes since 1500, according to new University of Arizona-led research. The study is the first to use shipwrecks as a proxy for hurricane activity.

The researchers found a 75 percent reduction in the number of Caribbean hurricanes from 1645-1715, a time with little sunspot activity and cool temperatures in the Northern Hemisphere.

DURHAM, N.C. -- In the largest analysis of its kind, researchers at the Duke Cancer Institute and other top cancer centers have found that the organ site where prostate cancer spreads has a direct impact on survival.

Patients with lymph-only metastasis have the longest overall survival, while those with liver involvement fare worst. Lung and bone metastasis fall in the middle.

"Smaller studies had given doctors and patients indications that the site of metastasis in prostate cancer affects survival, but prevalence rates in organ sites were small, so it was difficult to provide good guidance," said Susan Halabi, Ph.D., professor of biostatistics at Duke and lead author of the study published online March 7 in the Journal of Clinical Oncology.

Researchers at Columbia University's Mailman School of Public Health, with colleagues at the White House Social and Behavioral Sciences Team, the Massachusetts Institute of Technology, and the Centers for Medicare and Medicaid Services (CMS), conducted a randomized trial of informative letters aimed at suspected inappropriate prescribers of addictive substances like opioids and amphetamines. Top prescribers of these substances were identified and sent a letter informing them of their high prescribing rate. The investigators were unable to detect a statistically significant effect of the intervention on prescribing practices. Findings are published in the March issue of the journal Health Affairs.

Washington, D.C.--Scientists have long been puzzled about what makes Mercury's surface so dark. The innermost planet reflects much less sunlight than the Moon, a body on which surface darkness is controlled by the abundance of iron-rich minerals. These are known to be rare at Mercury's surface, so what is the "darkening agent" there?

Many viral diseases tend to become chronic - including infections with the HI virus. In persons affected, the immune response is not sufficient to eliminate the virus permanently. Scientists at the University of Bonn have now identified an immune factor which is partially responsible for this. Their results give rise to hopes for new therapeutic approaches. The work, which included researchers from the University of Cologne and the Technical University of Munich, is being published in the renowned journal "Nature Immunology."