A phase I study of the drug LOXO-101 appears to significantly reduce tumors in patients with varied types of genetically defined cancer, according to a study led by The University of Texas MD Anderson Cancer Center.

The results of the study, which followed patients with unique proteins called tropomyosin receptor kinase fusions (TRKs), were presented at the American Association for Cancer Research's annual meeting held April 16-20 in New Orleans.

"We saw efficacy with significant tumor regression in all six TRK fusion patients enrolled in the study," said David Hong, M.D., associate professor of Investigational Cancer Therapeutics. "We were surprised by the fact that the study demonstrated efficacy in every one of the TRK fusion-positive patients."

Encountering information suggesting that it may be tough to find a romantic partner shifts people's decision making toward riskier options, according to new findings from a series of studies published in Psychological Science, a journal of the Association for Psychological Science.

"Environmental cues indicating that one will have a relatively difficult time finding a mate can drive people to concentrate their investment choices into a few high-risk, high-return options," says psychological scientist Joshua Ackerman of the University of Michigan, lead author on the research. "This is true even when the decisions people are making are not explicitly relevant to romantic outcomes."

Researchers have characterized the prevalence and risk factors of fatty liver disease in patients who undergo liver transplantation. The findings, which are published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases, could have important implications for safeguarding transplant recipients' health.

A computer can probably beat you at chess and no one goes anywhere without a GPS. Transhumanist prophet Ray Kurzweil says we will ascend into being computers in a few years (though he also claims solar power will out-produce fossil fuels in a decade, so use caution when he is selling books) but some think it's the other way around, and that humans will instead be the ultimate supercomputers.

When people take the psychedelic drug LSD, they sometimes feel as though the boundary that separates them from the rest of the world has dissolved. Now, the first functional magnetic resonance images (fMRI) of people's brains while on LSD help to explain this phenomenon known as "ego dissolution."

As researchers report in the Cell Press journal Current Biology on April 13, these images suggest that ego dissolution occurs as regions of the brain involved in higher cognition become heavily over-connected. The findings suggest that studies of LSD and other psychedelic drugs can produce important insights into the brain. They can also provide intriguing biological insight into philosophical questions about the very nature of reality, the researchers say.

An analysis comparing the individual differences between over 40 strains of Zika virus (30 isolated from humans, 10 from mosquitoes, and 1 from monkeys) has identified significant changes in both amino acid and nucleotide sequences during the past half-century. The data, published April 15 in Cell Host & Microbe, support a strong divergence between the Asian and African lineages as well as human and mosquito isolates of the virus, and will likely be helpful as researchers flush out how a relatively unknown pathogen led to the current outbreak.

When we published a paper in 2013 finding 97% scientific consensus on human-caused global warming, what surprised me was how surprised everyone was.

Ours wasn’t the first study to find such a scientific consensus. Nor was it the second. Nor were we the last.

Athens, Greece - 15 April 2016: Patients have poor knowledge of warfarin which may increase their risk of serious side effects, according to research presented today at EuroHeartCare 2016 by Dr Kjersti Oterhals, a nurse researcher at Haukeland University Hospital in Bergen, Norway.1

"The stroke and bleeding complications from warfarin can be fatal," said Dr Oterhals. "Worldwide warfarin causes the most deaths from drug-related side effects. Patients need to know what foods and drugs have an impact on how warfarin works, and what to do if they have symptoms of an overdose or underdose."

In a new study, environmental pollutants found in fish were shown to obstruct the human body's natural defense system to expel harmful toxins. The Scripps Institution of Oceanography at UC San Diego-led research team suggests that this information should be used to better assess the human health risks from eating contaminated seafood. The study was published in the April 15 issue of the journal Science Advances.

A protein found in cells of nearly all plants and animals, called P-gp, acts as the cell's bouncer by expelling foreign chemicals from the body. P-gp is well known for its ability to transport therapeutic drugs out of cancer cells and, in some cases, rendering these cells resistant to multiple drugs at once.

Disastrous floods in the Balkans two years ago are likely linked to the temporary slowdown of giant airstreams, scientists found. These wind patterns, circling the globe in the form of huge waves between the Equator and the North Pole, normally move eastwards, but practically stopped for several days then -- at the same time, a weather system got stuck over Bosnia and Herzegovina, Serbia and Croatia that poured out record amounts of rain. The study adds evidence that so-called planetary wave resonance is a key mechanism for causing extreme weather events in summer. Further, the scientists showed that extreme rainfall events are strongly increasing in the Balkans, even more than the globally observed rise.