Inflammation has long a target in Alzheimer's disease studies so a new finding in Neuron is counterintuitive. In the study, researchers hace uncovered the mechanism by which anti-inflammatory processes may trigger the disease and this anti-inflammatory process might actually trigger the build-up of sticky clumps of protein that form plaques in the brain. These plaques block brain cells' ability to communicate and are a well-known characteristic of the illness.

The finding suggests that Alzheimer's treatments might need to be tailored to patients depending on which forms of Apolipoprotein E, a major risk factor for Alzheimer's disease, these patients carry in their genes.

Bacteria communicate using chemical signals and now scientists have described a previously unknown communication pathway that appears to be widely distributed - and even leads to pathogens.

The investigation of bacterial communication is valuable because those pathways are a possible therapeutic target for new medicines. If the relevant communication options are prevented, the bacteria cannot develop their pathogenic properties.

Common wisdom and prior economic research suggest that an inventor filing a patent would want to keep the technical know-how secret as long as possible. But a new study of nearly 2 million patents in the United States shows that inventors are not as concerned with secrecy as previously thought. Researchers found that since 2000, most inventors when given the choice opted to disclose information about their patents before patent approval - even small inventors - and this disclosure correlates with more valuable patents.

By Sayed Azam-Ali, University of Nottingham

Africa will be able to feed itself in the next 15 years.

That’s one of the big “bets on the future” that Bill and Melinda Gates have made in their foundation’s latest annual letter. Helped by other breakthroughs in health, mobile banking and education, they argue that the lives of people in poor countries “will improve faster in the next 15 years than at any other time in history”.

A medical researcher at the University of Warwick has found the 2,500 year-old Pythagoras theorem could be the most effective way to identify the point at which a patient's health begins to improve.

In a new paper, Dr Rob Froud from Warwick Medical School at the University of Warwick and Gary Abel from the University of Cambridge made the discovery after looking at data from ROC (Receiver Operating Characteristic) curves.

These curves were initially developed during World War II for the analysis of signals to help operators decide whether a blip on the screen was an enemy target or allied forces ships or aircrafts. In the 1980s, the curves were adopted by epidemiologists to help them decide at what point an individual has recovered from an illness.

Scientists have described a unique monoclonal antibody with the potential to treat Staphylococcus aureus (S. aureus) infections through the simultaneous neutralization of multiple key toxins produced by S. aureus, including alpha-hemolysin and four additional leukocidins. The findings are published online this week in the journal mAbs and demonstrate superior in vitro potency compared to antibodies targeting alpha-hemolysin alone. The mAb also shows high protective efficacy from lethal S. aureus infections in several animal models.

Fortifying food with folic acid saves about 1,300 babies each year from serious birth defects of the brain and spine known as neural tube defects (NTDs), according to new data published by the US Centers for Disease Control and Prevention in Morbidity and Mortality Weekly Report.The number of babies born in the United States with these conditions has declined by 35 percent since 1998.

About 3,000 pregnancies in the U.S. still are affected by neural tube defects annually. The March of Dimes says that even with folic acid-fortified grain products, many women still may not be getting enough folic acid so they recommend that all women take vitamins containing folic acid, though only about one-third of women do.