Many experimental and clinical data have demonstrated that antibiotic-resistance pathogens, such as Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), may play a vital role in priming chronic inflammation. There is thus a great need to develop novel antibacterial materials, and particularly those that are less likely to lead to bacterial resistance.
Now, in a paper appearing recently in Science Bulletin, a team of scientists at the National Center for Nanoscience and Technology, China, led by Guangjun Nie and Yuliang Zhao, has designed and synthesized bio-compatible and biodegradable ε-poly-lysine (EPL)/poly (ε-caprolactone) (PCL) nanoparticles (NPs), which have effective antibacterial activity and no significant cytotoxicity to mammalian cells.