Scientists have mapped out the genes that keep our cells alive, creating a long-awaited foothold for understanding how our genome works and which genes are crucial in disease like cancer.
A team of Toronto researchers, led by Professor Jason Moffat from the University of Toronto's Donnelly Centre, with a contribution from Stephane Angers from the Faculty of Pharmacy, have switched off, one by one, almost 18,000 genes -- 90 per cent of the entire human genome -- to find the genes that are essential for cell survival.
The data, published in Cell on November 25, revealed a "core" set of more than 1,500 essential genes. This lays the foundation for reaching the long-standing goal in biomedical research of pinpointing a role for every single gene in the genome.