Signaling molecules of the Wnt family are ubiquitous in biology. From cnidaria to man, they are responsible for forming the basic shape of all organisms. Without Wnt, our body would not have a top or bottom, front or rear. In addition, Wnt controls numerous other development processes in the body. Overly active Wnt signaling, on the other hand, promotes carcinogenesis.
Wnt binds to receptors on the cell surface and fulfils its "classic" functions via a highly complex cascade of protein interactions in the cell's interior. At the end of this intracellular signaling pathway, specific genes in the nucleus are read (transcribed) - the known Wnt signal stimulates transcription.