ANN ARBOR, Mich. -- When cancer cells compete with immune cells for glucose, the cancer wins. As a result, the immune T cells are not healthy and don't have the weapons to kill the cancer.
"If we have a way to manipulate the metabolic pathway, the T cells may be healthier," says senior author Weiping Zou, M.D., Ph.D., Charles B. de Nancrede Professor of Surgery, Immunology and Biology at the University of Michigan Medical School.
The finding, published in Nature Immunology, suggests a potential metabolic pathway against cancer.
"We know that if we provide glucose, the tumor uses it. One question we have is, can we make T cells resistant to glucose restriction? In our study, we define a mechanism that we can use as a model to test this," Zou says.