Research in The New England Journal of Medicine and Human and Molecular Genetics journals finds that mutation in the STAG3 gene is the major cause of human fertility disorders, as it provokes a loss of function of the protein it encodes.
STAG3 encodes a meiosis-specific subunit of the cohesin ring, the biological process through which, from a diploid somatic cell, a haploid cell or gamete is produced.
Cohesins are protein complexes that bind two straps of DNA and are implicated in its repair, replication and recombination, as well as in its chromosomal stability, transcription regulation, stem-cell pluripotency, and cell differentiation.
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