Researchers at the University of Pennsylvania School of Veterinary Medicine have derived uniparental embryonic stem cells - created from a single donor's eggs or two sperm - and, for the first time, successfully used them to repopulate a damaged organ with healthy cells in adult mice. Their findings demonstrate that single-parent stem cells can proliferate normally in an adult organ and could provide a less controversial alternative to the therapeutic cloning of embryonic stem cells.

"Creating uniparental embryonic stem cells is actually much more efficient than generating embryonic stem cells by cloning," said K.

In the digital age, organizing a photo collection has gone from bad to worse. The saying used to be that a picture is worth a thousand words. Now the question arises: what are a thousand pictures worth?

"Anyone who has a digital camera has the problem that they have more photos than they can possibly navigate," says Steve Seitz, associate professor of computer science & engineering. "And it's always a problem to find the photo that you're looking for."

With an aging population susceptible to stroke, Parkinson’s disease and other neurological conditions, and military personnel returning from Iraq and Afghanistan with serious limb injuries, the need for strategies that treat complex neurological impairments has never been greater.

One tack being pursued by neuroscientists and engineers is the development of “smart” neural prostheses. These devices are intended to restore function, through electrical stimulation, to damaged motor neural circuits – the long, slender fibers that conduct neurochemical messages between nerve cells in the brain and spinal cord.

A newly designed porous membrane, so thin it's invisible edge-on, may revolutionize the way doctors and scientists manipulate objects as small as a molecule.

The 50-atom thick filter can withstand surprisingly high pressures and may be a key to better separation of blood proteins for dialysis patients, speeding ion exchange in fuel cells, creating a new environment for growing neurological stem cells, and purifying air and water in hospitals and clean-rooms at the nanoscopic level.

Plants have an immune system that resists infection, yet 10% of the world's agricultural production is lost annually to diseases caused by bacteria, fungi, and viruses. Understanding how disease resistance works may help combat this scourge.

In a new study published online this week in the open-access journal PLoS Biology, Tessa Burch-Smith, Savithramma Dinesh-Kumar, and colleagues show how one aspect of the plant immune system is defined by the gene-for-gene hypothesis: a plant Resistance (R) gene encodes a protein that specifically recognizes and protects against one pathogen or strain of a pathogen carrying a corresponding Avirulence (Avr) gene.

In tobacco and its relatives, the N resistance protein confers resistance to infection by the Tobacco mosaic virus (TMV).

The Allen Brain Atlas, a genome-wide map of the mouse brain on the Internet, has been hailed as “Google of the brain.” The atlas now has a companion or the brain’s working molecules, a sort of pop-up book of the proteins, or proteome map, that those genes express.

The protein map is “the first to apply quantitative proteomics to imaging,” said Richard D. Smith, Battelle Fellow at the Department of Energy’s Pacific Northwest National Laboratory, who led the mapping effort with Desmond Smith of UCLA’s David Geffen School of Medicine.