COX-2 inhibitors are having a tough year. Vioxx was withdrawn voluntarily a few months ago and now Celebrex, the arthritis drug that blocks pain by inhibiting the COX-2 enzyme, has been shown in laboratory studies to induce arrhythmia, or irregular beating of the heart, via a pathway unrelated to its COX-2 inhibition.

University at Buffalo researchers discovered this unexpected finding while conducting basic research on potassium channels.

Celebrex (Celecoxib) has been taken by over 27 million patients since its approval by the FDA in 1998. The new research found that low concentrations of the drug, corresponding to a standard prescription, reduced the heart rate and induced pronounced arrhythmia in fruit flies and the heart cells of rats.

An endoscope is a flexible camera that travels into the body's cavities to directly investigate the digestive tract, colon or throat. Most of today's endoscopes capture the image using a traditional approach where each part of the camera captures a different section of the image. These tools are long, flexible cords about 9 mm wide, about the width of a human fingernail. Because the cord is so wide patients must be sedated during the scan.

A fundamentally new design has created a smaller endoscope that is more comfortable for the patient and cheaper to use than current technology.

Since we can’t sample the deepest regions of the Earth, scientists watch the velocity of seismic waves as they travel through the planet to determine the composition and density of that material.

A new study suggests that material in part of the lower mantle has unusual electronic characteristics that make sound propagate more slowly, suggesting that the material there is softer than previously thought.

The results in the January 25, 2008, issue of Science call into question the traditional techniques for understanding this region of the planet.

ESA’s orbiting gamma-ray observatory, Integral, has made the first unambiguous discovery of highly energetic X-rays coming from a galaxy cluster. The find has shown the cluster to be a giant particle accelerator.

The Ophiuchus galaxy cluster is one of brightest in the sky at X-ray wavelengths. The X-rays detected are too energetic to originate from quiescent hot gas inside the cluster and suggest instead that giant shockwaves must be rippling through the gas. This has turned the galaxy cluster into a giant particle accelerator.

Most of the X-rays come from hot gas in the cluster, which in the case of Ophiuchus is extremely hot, at 100 million degrees Kelvin. Four years ago, data from the Italian/ Dutch BeppoSAX satellite showed a possible extra component of high-energy X-rays in a different cluster, the Coma cluster.

Ice loss in Antarctica increased by 75 percent in the last 10 years due to a speed-up in the flow of its glaciers and is now nearly as great as that observed in Greenland, according to a new, comprehensive study by UC Irvine and NASA scientists.

In a first-of-its-kind study, an international team led by Eric Rignot, professor of Earth system science at UCI and a scientist with NASA’s Jet Propulsion Laboratory, Pasadena, Calif., estimated changes in Antarctica’s ice mass between 1996 and 2006 and mapped patterns of ice loss on a glacier-by-glacier basis. They detected a sharp jump in Antarctica’s ice loss, from enough ice to raise global sea level by 0.3 millimeters (.01 inches) a year in 1996, to 0.5 millimeters (.02 inches) a year in 2006.

Genes have the ability to recognise similarities in each other from a distance, without any proteins or other biological molecules aiding the process, according to new research published this week in the Journal of Physical Chemistry B. This discovery could explain how similar genes find each other and group together in order to perform key processes involved in the evolution of species.

Researchers of the Group of Recent Prehistory Studies (GEPRAN) of the University of Granada, from the department of Prehistory and Archaeology, have taken an important step to determine how life was in the Iberian Peninsula in the Bronze Age.

Since 1974, archaeologists from Granada, directed by professors Trinidad Nájera Colino and Fernando Molina González, have been working on the site of the Motilla del Azuer, in the municipal area of Daimiel (province of Ciudad Real), in search of the necessary information to reconstruct the day by day in this thrilling and unknown historical period.

The sites, known as “motillas”, represent one of the most peculiar types of prehistoric settlements in the Iberian Peninsula.

CLAREMONT, California, January 24 /PRNewswire/ --

- FAWE Increases Educational Access, Retention and Performance for Girls in 33 African Nations

Claremont McKenna College and the Kravis Leadership Institute announced today the selection of The Forum for African Women Educationalists (FAWE), to receive the third annual Henry R. Kravis Prize in Leadership.

The Kravis Prize, which carries a US$250,000 award designated to the honoree organization, recognizes extraordinary leadership in the nonprofit sector. FAWE was selected for its outstanding record providing an estimated 12 million girls and women with access to education, thereby contributing to improving their standard of economic and social well being.