No one knows you like you know yourself so if you think your memory is slipping, you may be onto something. Self-reported memory complaints are strong predictors of clinical memory impairment later in life.
Richard Kryscio, PhD, Chairman of the Department of of Biostatistics and Associate Director of the Alzheimer's Disease Center at the University of Kentucky, and colleagues asked 531 people with an average age of 73 and free of dementia if they had noticed any changes in their memory in the prior year. The participants were also given annual memory and thinking tests for an average of 10 years. After death, participants' brains were examined for evidence of Alzheimer's disease.