Aging

Researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration,

Inhibitors of the enzyme are being developed as a new anti-cancer target.

Aged and damaged cells frequently undergo a form of proliferation arrest called cellular senescence. These fading cells increase in human tissues with aging and are thought to contribute to age-related increases in both cancer and inflammation. The secretion of such inflammatory compounds as cytokines, growth factors, and proteases is called the senescence-associated secretory phenotype, or SASP.


Kidney stones are increasing in the U.S., a striking change from the historic pattern in which middle-aged white men were at highest risk for the painful condition.

Researchers, clinicians and public health experts have been aware of the overall increase in kidney stones in children and adolescents, but the current study provided greater clarity on the specific groups of patients at greatest risk by analyzing age, race and sex characteristics among children and adults in South Carolina over a 16-year period, from 1997 to 2012.


Life expectancy at birth is about six years shorter for White males than White females. This gap is about eight years for Blacks. Given the close correlation between declining health and early death, older males are effectively on average several years more aged than females. The detailed shapes of statistics could conceivably not support such ‘hyper-aging’, or it could conceivably result in only a few months of hyper-aging. The ‘Hyperaged Men Description’ is however strongly confirmed by the shape of for example Europe’s population pyramid. There is no far earlier onset of males dying, or any features that could point toward more exotic, perhaps purely biological explanations.

You may not think of men over 60 when you think of sex, but it happens. A lot. And when it can't happen the usual way, they are willing to pay for it - and they pay more and use less protection if they are a regular client.

Obviously the assumption, or documented medical fact, is that both parties are disease-free, but it still involves a certain amount of trust - and a certain amount more money.

The new survey in the American Journal of Men's Health asked about the habits of American men between the ages of 60 and 84 who pay for sex and found that the older they were, the more frequently they paid for sex and the more likely they were to have experienced unprotected sexual intercourse multiple times with their favorite commercial sex providers. 


A paper in the International Journal of Epidemiology seeks to dismiss the concept of 'fat but fit' and instead suggest that the protective effects of high fitness against early death are reduced in obese people. 

The detrimental effects of low aerobic fitness in older people have been well documented but few studies have investigated a direct link between aerobic fitness and health in younger populations. A study in Sweden followed 1,317,713 men for a median average of 29 years to examine the association between aerobic fitness and death later in life, as well as how obesity affected these results. The subjects' aerobic fitness was tested by asking them to cycle until they had to stop due to fatigue.


It's not enough to stay fit as you age if you want to avoid falls, according to an analysis of how many hours older people exercised and how well they performed on four balance tests.

Every year around 30 percent of all people aged 65 and older experience a fall. In the same age group, falls account for 40 percent of all injury-related deaths worldwide. Injuries from falls can have serious consequences. One in four seniors who break their hip die within a year, and quality of life can be greatly reduced for survivors.

A commonly used skin care ingredient is one of several newly identified compounds that can mimic the life-extending effect of a starvation diet, finds a new lab study.

Calorie restriction, a dramatic reduction in calorie intake, has been found to slow down the aging process in several animal models. Mice weaned on it from birth live longer but to-date it has not been shown to work in humans, since such an experiment on babies would be a human rights violation. Efforts are on to try and create drugs that can reproduce this effect, without the side effects of starvation.


The flu virus infects up to one-fifth of the U.S. population each year and kills thousands of people, many of them elderly. A new study explains why the flu vaccine is less effective at protecting older individuals, the people it is supposed to protect. 

Flu vaccines, which contain proteins found in circulating viral strains, offer protection by eliciting the production of antibodies -- proteins that help the immune system identify pathogens and protect against infectious disease. While vaccination is considered the most effective method for preventing influenza, it is less effective in the elderly. But until now, the molecular mechanisms underlying this decrease in vaccine efficacy were unknown.


Many strokes that required immediate treatment in emergency rooms may have been preventable, but stroke prevention has not advanced the way therapy for acute stroke has. Stroke prevention has fallen by the wayside as stroke patient outcomes have improved but the close monitoring of blood pressure, cholesterol levels and cardiac conditions remain important, finds a paper in JAMA Neurology.

Using a prevention scale they developed for this study, University of California Irvine neurologist Dr. Mark Fisher and colleagues discovered that 76 percent of acute stroke patients exhibited some degree of stroke preventability, while 26 percent exhibited high preventability.


Two studies conducted 20 years apart in England reveal an apparent increase in healthy ageing, or years lived healthily, reflecting less cognitive impairment; and an increase in the proportion of life lived healthily, through a larger proportion of years lived with disability but less rather than more severe disability. The research from Professor Carol Jagger at the Institute of Health and Society, Newcastle University, UK, and colleagues is published in The Lancet.