Pharmacology

Where is Mel Brooks when you need him?

Ever since Chipotle's self-righteous claim (which isn't even true) that the company was removing GM ingredients from its food because "it doesn't align with [the company's] position," just about everything conceivable went wrong.  It's now a bit of a novelty to find a news day when they haven't poisoned someone.

Isotretinoin (popularly marketed as Accutane) is used to treat severe acne and has been approved in Canada since 1983. The average age of isotretinoin users in Canada is estimated to be 24 years, and half of all prescriptions are written for females, a concern because it can severely harm a fetus, causing craniofacial, cardiac and central nervous system defects, as well as a high likelihood of miscarriage or medical termination. 

Even Canada's program recommends informed written consent, two negative pregnancy tests before beginning treatment and the use of two reliable birth control methods during treatment, numerous studies in Canada and internationally have indicated poor adherence to pregnancy prevention guidelines among women taking isotretinoin. 


The smoking cessation aids varenicline (Chantix) and bupropion (Zyban) do not show a significant increase in neuropsychiatric adverse events compared to the nicotine patch and a placebo, according to data published in The Lancet.

After reports claiming varenicline and bupropion might cause adverse neuropsychiatric events, such as increased agitation, depression, hostility or suicidal behavior, the
Food and Drug Administration (FDA) requested that both medications carry boxed warnings in their labeling, which resulted in limitation in use and thus fewer ways to quit.


When people take the psychedelic drug LSD, they sometimes feel as though the boundary that separates them from the rest of the world has dissolved. Now, the first functional magnetic resonance images (fMRI) of people's brains while on LSD help to explain this phenomenon known as "ego dissolution."

As researchers report in the Cell Press journal Current Biology on April 13, these images suggest that ego dissolution occurs as regions of the brain involved in higher cognition become heavily over-connected. The findings suggest that studies of LSD and other psychedelic drugs can produce important insights into the brain. They can also provide intriguing biological insight into philosophical questions about the very nature of reality, the researchers say.


Type II diabetes is booming in the developed world and obviously obesity is the primary driver. A new paper contends sugar is a primary driver of that obesity, rather than consuming too many calories and not exercising, and so sugar addiction should be treated just like cigarettes.

While pharmaceutical companies will be delighted by the efforts of scholars in the pay-to-publish journal PLOS ONE to give them a brand new market, claims of sugar addiction, while a popular fad for the last few years, have not really held up. Nonetheless, neuroscience Professor Selena Bartlett from 
Queensland University of Technology


A new survey has documented that black Americans are systematically under-treated for pain relative to white Americans, and the authors allege it is due to the over-prescription and over-use of pain medications among white patients and the under-prescription of pain medications for black patients. Statistics show that black patients are under-treated for pain not only relative to white patients, but relative to World Health Organization guidelines. 


Valeant Pharmaceuticals is in the British Columbia Supreme Court hoping to avoid lawsuit class-action status for ignoring their own scientists and claiming the popular "cold and flu remedy" Cold-fX actually works for cold and flu.

Boston, MA - Botswana appears to have achieved very high rates of HIV diagnosis, treatment, and viral suppression--much better than most Western nations, including the United States--according to a new study from Harvard T.H. Chan School of Public Health and colleagues in Botswana. The findings suggest that even in countries with limited resources where a large percentage of the population is infected with HIV, strong treatment programs can help make significant headway against the HIV/AIDS epidemic.


An investigation on the effect of fish oil supplements for muscle growth reveals the tablets do not give gym-goers an advantage in the weight room.

Supplements are a protected class in the United States, easily claiming drug effects without being forced to prove they work the way drugs do. Most are just expensive placebos, more akin to homeopathy and superstition than medicine, though they are heavily promoted by alternative medicine gurus such as Dr. Joe Mercola and Dr. Oz.

Many of the drugs we use in hospitals, such as antibiotics, antifungals and anti-cancer drugs, are produced by bacteria that live in the soil beneath our feet.