Pharmacology

A new study by researchers at the University of Bari Aldo Moro, Bari, Italy, Geriatric Unit&Laboratory of Gerontology and Geriatrics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy, and Istituto Superiore di Sanità (ISS), Roma, Italy, estimates the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI), evaluating 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging (ILSA), a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. These findings are published in the Journal of Alzheimer's Disease.


A class of hormonal drugs called aromatase inhibitors substantially reduce the risk of death in postmenopausal women with the most common type of breast cancer, a major study of more than 30,000 women shows.

The research underlines the importance of aromatase inhibitors in the treatment of oestrogen receptor (ER)-positive breast cancer - and shows they reduce risk of death by significantly more than the older hormonal treatment tamoxifen.

The study published in The Lancet is relevant to postmenopausal women with ER-positive breast cancer, which accounts for over 80 per cent of cases which occur after the menopause. Each trial had used both aromatase inhibitors and tamoxifen at various times during the course of treatment.


“I saw a werewolf with a Chinese menu in his hand,

Walkin' through the streets of Soho in the rain,

He was lookin' for the place called Lee Ho Fooks,

Gonna get a big dish of beef chow mein.”

Aaahoo! …."

Warren Zevon, 1978


Taking a combination of antidepressants and common painkillers is associated with an increased risk of bleeding soon after starting treatment, finds a study in BMJ.

The researchers say their results may have been affected by other unmeasured or unknown factors and should be interpreted with caution. However, they suggest special attention is needed when patients use both these classes of drugs together.

Depression produces the greatest decrement in health of all common chronic conditions and depression in older people is an important public health problem.


New research finds that high vitamin C concentrations in the blood from the intake of fruit and vegetables are associated with a reduced risk of cardiovascular disease and early death.

Fruit and vegetables are healthy, we all know that, and the new paper by scholars from the University of Copenhagen and Herlev and Gentofte Hospital says that the risk of cardiovascular disease and early death falls with a high intake of fruit and vegetables, and that this may be due to vitamin C. 


Pain treatment researchers have discovered thousands of new peptide toxins hidden deep within the venom of just one type of Queensland cone snail. The scientists hope the new molecules will be promising leads for new drugs to treat pain and cancer.
It must be nice to have a job with so much free time on your hands that you can do just about anything, regardless of merit, and not only get away with it, but, rather, be rewarded for it.

Our dear friends, the Environmental Working Group (EWG), perhaps the most scientifically flawed organization out there (and this is no small accomplishment) have decided to take on the (all of a sudden) life and death issue of children drawing with crayons.

Hope you were sitting down when you heard about this.

This non-issue arises from a report, entitled “EWG Tests Find Asbestos in Kids’ crayons, Crime Scene Kits— Even trace exposures to lethal asbestos fibers can cause cancer, other diseases.”
A common arthritis drug may also be an effective way to help treat patients with blood cancers—at one thousandth the cost of another drug that works the same way.

Myeloproliferative neoplasms (MPN) cause an overproduction of blood cells resulting in symptoms that include night sweats, itching, and tiredness. MPNs are most often diagnosed in people in their 50s and 60s. Current treatment is limited to aspirin, removal of excess blood, and mild chemotherapy. 
What have I been doing for the last twoweeks, you ask? I’ve been waiting for news on the antibiotic front.  The G7 came out with a completely lame statement that has no specific commitments.  They suggest they meet together again to share ideas for “best practices.”  What we really need is money.  But again, no one wants to talk about that. 
This isn't the Dr. Oz show or some nutrition site selling Vitamin D supplements or whatever the big Superfood/Miracle Vegetable craze is this week, 'miracle' is a bit of a dirty word in science. But when it fits, you have to use it.

And Hepatitis C may have gotten its miracle. 

It's not well known, Hepatitis C does not have the PR of diseases like AIDS, but 3 million people have it, many of them Baby Boomers. Some got it of their own volition, using skin poppers or needles for drugs, but hygiene was a different beast 50 years ago and it was also possible to get it just by going to the dentist.