Pharmacology

Marijuana became popular as a recreational drug and as its legalization movement became more popular, studies were conducted on its therapeutic properties. Medical cannabis is often used by sufferers of chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite, and other symptoms. But self-reported milder symptoms often claim that only marijuana helps. Women have 50% of prescription-level pain, for example, but men have gotten 80% of the 'medical marijuana' cards, so objective data is lacking.


Hospitalization due to surgery or critical illness can lead to cognitive dysfunction -   inattention, disorganized thinking, altered consciousness and prolonged disruptions in learning and memory functions - in some patients, especially the elderly.

The mechanisms whereby surgery and/or anesthesia may lead to cognitive impairment remain unclear but research has demonstrated that inflammation and release of pro-inflammatory molecules, like cytokines, play an important role in causing brain inflammation and cognitive decline after surgery.


Did you ever have breast milk or spinach? You might as well start shooting up heroin.

If dihydrogen monoxide doesn't scare you enough, food activists have been rehashing an old term - opiates. 

Extended use of the common antibiotic azithromycin may prolong the time between hospitalizations for patients suffering from chronic obstructive pulmonary disease (COPD), according to a post-hoc analysis of a multicenter study which compared the hospitalization rates of patients treated with a 12-month course of azithromycin to the rates of those treated with placebo. 


A novel approach to obstructing the runaway inflammatory response implicated in some types of asthma has shown promise in a Phase IIa clinical trial, according to researchers.

The randomized, double-blind, placebo-controlled trial tested the efficacy and safety of the monoclonal antibody, dupilumab, in patients with "persistent, moderate-to-severe asthma" and elevated eosinophils, which are immune cells that mobilize in response to allergens and infections and are commonly seen in asthma.

Dupilumab, a fully human monoclonal antibody discovered by Regeneron Pharmaceuticals and being developed by Regeneron and Sanofi, thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin-4 and interleukin-13.


Tiotropium delivered by the Respimat(R) Soft Mist(TM) Inhaler (SMI) increases time to first severe exacerbation and first episode of asthma worsening across a broad spectrum of patients who remain symptomatic despite at least inhaled corticosteroids (ICS) / long-acting beta2-agonists (LABA) therapy.

The results are from pre-planned subgroup analyses of data from the PrimoTinA-asthma(TM) Phase III studies being presented for the first time today at the 2013 American Thoracic Society (ATS) congress in Philadelphia, Pennsylvania.


The drug candidate J147 was able to reverse memory deficits and improve several aspects of brain function in mice with advanced symptoms of Alzheimer's disease, according to a new study.  


An anti-cocaine vaccine has been successfully tested in primates, bringing it a step closer to human clinical trials.


Since marijuana is fast becoming legal again in America, it seems strange to be calling cigarettes a 'gateway' to it, but anti-smoking campaigns are almost as large a business as tobacco and so a paper at the Pediatric Academic Societies (PAS) annual meeting in Washington, D.C., today supports the notion that cigarettes are a gateway to marijuana. 

And, like everyone who picks a position and then wants data to support it, they used surveys of students. They found that students who smoked marijuana smoked more cigarettes than those who just smoked cigarettes. Cigarettes are so demonized a successful public relations campaign against drugs might be that it leads to more smoking. That will likely work far better than a fried egg in a television commercial.


Prenoxad Injection is a pre-filled syringe containing 1mg/ml naloxone hydrochloride solution for injection. Martindale Pharma announced the world's first licensed emergency treatment for acute opioid related overdose for use at home or other non-medical settings. 

There are more than 1,000 fatal opioid related overdoses just in the UK each year, with a significant proportion of these being witnessed by other people who use drugs, family members and loved ones.