Pharmacology

Between 2001 and 2010, there were dramatic increases in Emergency Room prescriptions of opioid analgesics, such as Percocet, Vicodin, oxycodone and Dilaudid.

No surprise there, America is increasingly over-medicated, be it on supplements, homeopathy or legitimate treatments.

And it's going to get worse. If current trends under the Affordable Care Act persist, fewer and fewer doctors will accept government plans, and that means even more people will go to the ER, at far higher cost. ER doctors have to treat a lot of people and 'pain' is an entirely subjective claim, one of the last vestiges remaining of symptom-based diagnosis in the field.


While there's no genetic basis for anorexia nervosa, psychiatrists say there may be a chemical treatment - oxytocin, the 'love hormone'.  


A team of researchers led by Mayland Chang and Shahriar Mobashery have discovered a new class of antibiotics to fight bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant bacteria that threaten public health. 


Glioblastoma is the most common primary malignant adult brain tumor and, despite treatment advances in recent years, the average survival of patients enrolled in clinical trials is less than 16 months.

Few patients live beyond five years.

Glioblastoma
tumors are characterized by angiogenesis — the formation of new blood vessels that support tumor growth stimulated by the GBM-produced vascular endothelial growth factor A (VEGF-A).

Bevacizumab is a monoclonal antibody that targets VEGF-A production to block the growth of tumor-derived blood vessels.


On face value, if you read Anita Clayton's Huffington Post piece entitled “The FDA, Sexual Dysfunction and Gender Inequality,” you could not come to any conclusion other that the FDA is overtly sexist.

Canada has gotten a bizarre sort of entrepreneurial in the last decade. With Toronto mayor Rob Ford making headlines and a booming ecstasy industry, they have become a party destination. 

And that success has led to even newer designer highs which are flooding the drug market.

"The chemists who are making these drugs are coming up with about 10 new drugs per year; the legislation cannot keep up with the market," said University of Alberta pharmacologist Alan Hudson, who studies how ecstasy and other drugs affect brain neurochemistry. "The best way forward is to educate people that they're playing Russian roulette—the health risks from taking these drugs are high, and potentially lethal."


In America, after a startling homicide occurs, there is a lot of talk about society and guns and violence culture and what we should ban, everything from guns to video games. Much less discussed, because we don't want to demonize mental illness, is the overwhelming prevalence of psychiatric medications in those events.

It does the public and patients a disservice to dismiss one factor and focus solely on others; we could end up solving the wrong problem and helping no one at all.


If you were pregnant, did you ever take a Tylenol?

If not, you have unreal levels of tolerance for discomfort but if you did, and you think your child is hyperactive, a new study may have some answers. Not 'why' answers, just a 'perhaps' answer. But look for mainstream media to declare that Tylenol causes attention-deficit/hyperactivity disorder (ADHD) in kids.

Ecstasy, marijuana (including synthetic cannabinoids sold as ‘Spice’ and ‘Incense’) and various psychoactive ‘legal highs’ have surged in popularity and Canada has become a major criminal hub for ecstasy. 

Recent deaths have been linked to paramethoxymethamphetamine (PMMA) in ecstasy pills and with Canadian producing most of the ecstasy in the North American market, a timely paper in Drug Science Policy and Law looks at trends in ecstasy adulteration and the facts around PMA/PMMA-linked deaths. 


In America, social authoritarians are ban-happy but the Canadian authors also argue for an alternative to a new ban.

The review finds: 


Last week, an article appeared in The Lancet Neurology (doi:10.1016/S1474-4422(13)70278-3) which reviewed studies and asserted that there is a "pandemic" of developmental toxicity. This led to a press release and a variety of stories in the media linking things like pesticides to brain disorders in children.