Marijuana and its main psychoactive component, THC, exert a plethora of behavioral and autonomic effects on humans and animals.
Some of these effects are the cause of the widespread illicit use of marijuana, while others might be involved in the potential therapeutic use of this drug for the treatment of several neuronal disorders. The great majority of these effects of THC are mediated by cannabinoid receptor type 1 (CB1), which is abundantly expressed in the central nervous system. The exact anatomical and neuronal substrates of each action, however, were previously unknown.
Using an advanced genetic approach, Krisztina Monory and colleagues at the Johannes Gutenberg University Mainz discovered that specific neuronal subpopulations mediate the distinct effects of THC.
In their study, the researchers generated mutant mice lacking CB1 expression in defined neuronal subpopulations but not in others. These mice were treated with THC, and typical effects of the drug on motor behavior, pain, and thermal sensation were scored. Their discovery of the neural substrates underlying specific effects of THC could lead to a refined interpretation of the pharmacological actions of cannabinoids. Moreover, these data might provide the rationale for the development of drugs capable of selectively activating CB1 in specific neuronal subpopulations, thereby better exploiting cannabinoids’ potential therapeutic properties.
Citation: Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, et al (2007) Genetic dissection of behavioural and autonomic effects of D9-tetrahydrocannabinol in mice. PLoS Biol 5(10): e269.doi:10.1371/journal.pbio.0050269
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Kudos To "The Independent" Newspaper For Debunking Nibiru "Blood Moon" Hoax
- USDA Microbiologist Warns Bacteria In Vaping Products May Be A Health Concern
- Control Cancer By Making The Tumor Cell Environment Hostile
- 20 Cent School Intervention Stops Unhealthy Weight Gain In Children
- Your Microbiome Did Not Cause Your Weight Problem
- The Seasonal Spike In Divorce Filings
- Gödel,Frenkel, Kurzweil, and Hawkins on AI
- "Stacey, I already have. But sometimes I find new ways to explain these things which seem to help..."
- "Mr walker please would you be able to demonstrate how this cant be real or at least show hard evidence..."
- "germs, microbes, bacteria, etc.apparently cannot feed on pg, vg, or nicotine. The flavorings commonly..."
- "Oh, I wonder if you were lucky enough to see a rare sun mirage? Actually every time you see..."
- "I dont know much about this topic, however, I am certain of what I saw yesterday at sunset and..."
- Breast Cancer: Genomics May Show Where Chemo Might Not Be Needed
- Gallup Poll: Great Example of How to Bias a Social Science Study
- Another Kardashian Craze Debunked
- Fad Friday: Ditch The Body Wrap!
- Commonly Cited Stat of 10 Bacteria for Every 1 Human Cell Is Wrong
- Why The EpiPen And Other Generic Drugs Are So Expensive
- Activity tracker uses heart rate to personalize amount of exercise needed to prevent death
- Moderate physical activity linked with 50 percent reduction in cardiovascular death in over-65s
- 20 cent school intervention stops unhealthy weight gain in children
- Low socioeconomic status associated with higher risk of second heart attack or stroke
- Smartphone detects atrial fibrillation with existing hardware