Marijuana and its main psychoactive component, THC, exert a plethora of behavioral and autonomic effects on humans and animals.
Some of these effects are the cause of the widespread illicit use of marijuana, while others might be involved in the potential therapeutic use of this drug for the treatment of several neuronal disorders. The great majority of these effects of THC are mediated by cannabinoid receptor type 1 (CB1), which is abundantly expressed in the central nervous system. The exact anatomical and neuronal substrates of each action, however, were previously unknown.
Using an advanced genetic approach, Krisztina Monory and colleagues at the Johannes Gutenberg University Mainz discovered that specific neuronal subpopulations mediate the distinct effects of THC.
In their study, the researchers generated mutant mice lacking CB1 expression in defined neuronal subpopulations but not in others. These mice were treated with THC, and typical effects of the drug on motor behavior, pain, and thermal sensation were scored. Their discovery of the neural substrates underlying specific effects of THC could lead to a refined interpretation of the pharmacological actions of cannabinoids. Moreover, these data might provide the rationale for the development of drugs capable of selectively activating CB1 in specific neuronal subpopulations, thereby better exploiting cannabinoids’ potential therapeutic properties.
Citation: Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, et al (2007) Genetic dissection of behavioural and autonomic effects of D9-tetrahydrocannabinol in mice. PLoS Biol 5(10): e269.doi:10.1371/journal.pbio.0050269
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Erupting Bardarbunga Volcano In Iceland Sits On A Massive Magma Hot Spot
- Genetically Modified Stem Cells Kill Brain Tumors
- Researchers Created A Laser Bullet To See What It Would Look Like - And Here It Is
- How Gut Bacteria Ensure A Healthy Brain – and Could Play A Role In Treating Depression
- Psychiatry Should Switch From Symptom-based Prescriptions To Target-based
- Cold Fusion: A Better Study On The Infamous E-Cat
- Ebola's Evolutionary Roots Are Ancient
- "Both in this article and the press release from ASU Biodesign are carefully worded allusion to..."
- "These are idiotic concerns. Non-steroidal anti-inflammatory drugs aren't always used to treat inflammation..."
- "So 'volcano boarding' is apparently a thing for the well-to-do hipster extreme sports community..."
- "If we had a contest between the USA and UK, perhaps weighted according to population or GDP, which..."
- "Hi Tommaso,I stumbled on this presentation; the plot on slide nr. 4 might be of interest to you..."
- How to sell a toxic pesticide the smart way–call it organic
- Leftist dystopia? Anti-technology fever animates opposition to GMOs and other ‘disruptive’ technologies
- CDC faced a nearly impossible balancing act with Ebola, and failed
- Why Chobani reversed course, making yoghurt only from milk from cows not fed GMO grain
- Monterey, California, hotbed of anti-GMO activism, home to new GMO corn farm
- Evolution is sometimes messy or even outright ridiculous