Marijuana and its main psychoactive component, THC, exert a plethora of behavioral and autonomic effects on humans and animals.
Some of these effects are the cause of the widespread illicit use of marijuana, while others might be involved in the potential therapeutic use of this drug for the treatment of several neuronal disorders. The great majority of these effects of THC are mediated by cannabinoid receptor type 1 (CB1), which is abundantly expressed in the central nervous system. The exact anatomical and neuronal substrates of each action, however, were previously unknown.
Using an advanced genetic approach, Krisztina Monory and colleagues at the Johannes Gutenberg University Mainz discovered that specific neuronal subpopulations mediate the distinct effects of THC.
In their study, the researchers generated mutant mice lacking CB1 expression in defined neuronal subpopulations but not in others. These mice were treated with THC, and typical effects of the drug on motor behavior, pain, and thermal sensation were scored. Their discovery of the neural substrates underlying specific effects of THC could lead to a refined interpretation of the pharmacological actions of cannabinoids. Moreover, these data might provide the rationale for the development of drugs capable of selectively activating CB1 in specific neuronal subpopulations, thereby better exploiting cannabinoids’ potential therapeutic properties.
Citation: Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, et al (2007) Genetic dissection of behavioural and autonomic effects of D9-tetrahydrocannabinol in mice. PLoS Biol 5(10): e269.doi:10.1371/journal.pbio.0050269
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- "Hi Andrea, okay I will take your suggestions and see what happens! We can then vote some time..."
- "Oh I think it would revolutionize biology. I'm actually working on a presentation for the think..."
- "Sorry for going OT, but I like your writings so much that I think about you when I encounter other..."
- "If it is a question that interests and inspires you, I'd like to see you reasoning about what implications..."
- "Hi Tommaso, I cannot resist giving my two cents. It goes without saying that it is really pure..."