Marijuana and its main psychoactive component, THC, exert a plethora of behavioral and autonomic effects on humans and animals.
Some of these effects are the cause of the widespread illicit use of marijuana, while others might be involved in the potential therapeutic use of this drug for the treatment of several neuronal disorders. The great majority of these effects of THC are mediated by cannabinoid receptor type 1 (CB1), which is abundantly expressed in the central nervous system. The exact anatomical and neuronal substrates of each action, however, were previously unknown.
Using an advanced genetic approach, Krisztina Monory and colleagues at the Johannes Gutenberg University Mainz discovered that specific neuronal subpopulations mediate the distinct effects of THC.
In their study, the researchers generated mutant mice lacking CB1 expression in defined neuronal subpopulations but not in others. These mice were treated with THC, and typical effects of the drug on motor behavior, pain, and thermal sensation were scored. Their discovery of the neural substrates underlying specific effects of THC could lead to a refined interpretation of the pharmacological actions of cannabinoids. Moreover, these data might provide the rationale for the development of drugs capable of selectively activating CB1 in specific neuronal subpopulations, thereby better exploiting cannabinoids’ potential therapeutic properties.
Citation: Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, et al (2007) Genetic dissection of behavioural and autonomic effects of D9-tetrahydrocannabinol in mice. PLoS Biol 5(10): e269.doi:10.1371/journal.pbio.0050269
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Will Asteroid 2012 TC4 Hit Earth in October 2017?
- Standards needed for post-conviction review of scientific evidence
- The Era Of The Atom
- Can Moons Have Moonlets? Or Rings? Moonlets Of Pluto's Moons?
- Thorium Can Serve As A Nuclear Fuel For Commercial Electricity Generation
- Singular Value Decomposition Method Increases Accuracy Of Ovarian Cancer Diagnosis
- Patrick Matthew, The Overlooked Third Man Of Natural Selection
- "I used to think the same. Internal Combustion Engines are part of a group known as Heat Engines..."
- "The linear range of an alpha particle is very small in materials, typically measured in microns..."
- "Right good point :). I wonder if Pluto will have irregular moons also :).Here is a plot of the..."
- "BTW several of the other KBOs have moons Indeed, counting Pluto, then amongst the 8 largest, five..."
- "Well would be best of all to do both :). Voyager 1 could have visited Pluto before perihelion...."
- Dutch doctors withhold/withdraw treatment in many elderly patients
- New guidelines for how to treat a first seizure
- Soil can limit ability of plants to slow climate change
- Women who smoke more likely to give birth to twins
- It shouldn't be there: Black hole hunters use Henize 2-10 to tackle a cosmic conundrum