Cancer Research

People with the most common type of lung cancer whose disease has spread to the brain could be spared potentially harmful whole brain radiotherapy, according to new research published in The Lancet. The phase 3 randomized trial found that whole brain radiotherapy had no beneficial effect on length or quality of survival over treatment with steroids and other supportive care.

Despite its widespread use, until now there has been no robust evidence to determine whether whole brain radiotherapy, which can have substantial side effects (eg, fatigue, nausea, neurotoxicity), is better than best supportive care alone in terms of prolonging life or improving quality of life.


While preventing cancer is impossible, what will be possible soon is making cancer far more manageable, like diabetes, and treatment far less debilitating. A new drug delivery system called a "metronomic dosage regimen," uses significantly lower doses of chemotherapeutic drugs but at more frequent time intervals. This would have multiple goals of killing cancer cells, creating a hostile biological environment for their growth, reducing toxicity from the drug regimen and avoiding the development of resistance to the cancer drugs being used.


The duration of overweight and obesity in women's adult lives is correlated with cancer risk in a PLOS Medicine longitudinal study.


A new paper in
EBioMedicine finds that infection with the Epstein-Barr virus (EBV), one of eight known viruses in the herpes family to infect humans, may put some women at increased risk for developing breast cancer.  

EBV is one of the most common viruses and is best known as the cause of infectious mononucleosis. More than 90 percent of the world's population carries EBV, and most individuals experience no effects from infection, but it has been linked to everything from cancer to Hodgkin's disease so it's hard to know which are real.


Given the anticipated increase in cancer imaging over the next decade [1, 2], radiologists need to solidify their position as central members of the cancer team by identifying toxicity early and understanding the implications of their findings.

A team of radiologists and researchers led by Stephanie A. Holler Howard, of the Department of Radiology at the Dana Farber Cancer Institute in Boston, write in the American Journal of Roentgenology that they want to broaden the radiologist's understanding of imaging-evident toxicity. 


Scientists have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease. 
Stem cells were first discovered in Toronto in 1961 at the
Princess Margaret Cancer Centre
 by Drs. James Till and Ernest McCulloch, a discovery that launched a new field of science and formed the basis of all stem cell research that continues to this day. 


Cancer centers promoting their services dramatically increased their advertising spending from 2005 to 2014, and  9 of the 20 that accounted for the bulk of the spending were National Cancer Institute-designated centers, so they were using taxpayer funding to advertise to taxpayers to get taxpayers to come to their centers.  Five were for-profit institutions.


Magnetic Resonance Imaging (MRI) is useful in detecting breast tumors and in cancer evaluation but its current pre-operative use in breast conserving surgery isn't helping patients as it should. 

Traditionally, patients who are scheduled to undergo breast-conserving lumpectomy for breast cancer undergo a breast MRI prior to surgery to help inform the surgeon about the size, shape, and location of the tumor. The issue is that MRIs are performed with the patient lying face down, but then the surgery is performed with the patient lying face up. 


Glioblastomas are often resistant to the one type of drug that breaks the blood-brain barrier. HealthHub You find yourself sitting in your doctor’s surgery. It’s only been a few days since your initial visit to check on these pounding headaches you’ve been waking up with, along with some dizziness, nausea and vomiting, and a general drowsy and disconnected feeling.

Chimeric antigen receptor (CAR) T cell therapy, which edits a cancer patient's T cells to recognize their tumors, has successfully helped patients with aggressive blood cancers but has yet to show the ability to treat solid tumors. To overcome this hurdle, researchers genetically engineered human T cells to produce a CAR protein that recognizes a glycopeptide found on various cancer cells but not normal cells, and then demonstrated its effectiveness in mice with leukemia and pancreatic cancer. Their proof-of-concept study appears June 21 in Immunity.