Researchers  have uncovered a new way to stimulate activity of immune cell opiate receptors, leading to efficient tumor cell clearance - their pharmacological approach can activate the immune cells to prevent cancer growth through stimulation of the opiate receptors found on immune cells.

Among cancer deaths worldwide, lung cancer is the leader. 

It isn't just the tumor cells, the growth of blood vessels controls tumors development and blood vessel growth is controlled by several signalling molecules. Scientists have discovered a molecule, phosphodiesterase PDE4, that plays a key role in this process and they have succeeded in reducing tumor growth in their experiments by blocking it.

Prostate cancer is a type of cancer that starts in the prostate gland and usually occurs in older men. Recent data shows that about 1 in 36 men will die of prostate cancer. Estimated new cases and deaths from this disease condition in the US in 2012 alone are 241,740 and 28,170, respectively. Current treatment options for patients include surgery, radiation therapy, hormone therapy, chemotherapy, and immune therapy. Unfortunately, these are associated with considerable complications and/or severe side effects.

A study published in CANCER found that while dental X-rays are necessary, frequent dental X-rays in the past led to an increased risk of developing the most commonly diagnosed primary brain tumor in the United States.

Ionizing radiation is the primary environmental risk factor for developing meningioma, which is the most frequently diagnosed primary brain tumor in the United States. Dental x-rays are the most common artificial source of exposure to ionizing radiation for individuals living in America.

Early cancer diagnosis is vital for treating breast cancer - and one in eight women will be diagnosed with breast cancer, according to an article in Molecular&Cellular Proteomics - but early detection is still challenging as testing by mammography remains cumbersome, costly, and in many cases, cancer can only be detected at an advanced stage.

A team based in the Dept. of Biomedical Engineering at McGill University's Faculty of Medicine has developed a new microfluidics-based microarray that could change how and when cancer is diagnosed.

Most breast cancers are categorized as estrogen-receptor positive, which means they are hormone sensitive and may need estrogen to grow. Patients with this type of cancer often respond favorably to aromatase inhibitors, like tamoxifen, which cause cell death by preventing estrogen from reaching the cancerous cells. Over time, the disease often becomes resistant to estrogen deprivation from the drugs, making treatment options more limited. 

New findings from the AACR Annual Meeting identified a pair of proteins that could play a crucial role in restoring treatment sensitivity to these resistant cancerous cells—possibly leading to more treatment options in the future.

Utopia is a perfect world where we can eat to our heart's content without without getting heart disease or diabetes or even cancer.  In mice, Utopia may be coming closer. Mice with an extra dose of a known anti-cancer gene called Pten lose weight even as their appetites grow. They also live longer - but not just because they aren't getting cancer.

One of the animals' youthful secrets is hyperactive brown fat, which burns energy instead of storing it. The findings add to evidence that tumor suppressors aren't designed only to protect us against cancer, the researchers say. They also point to new treatment strategies aimed to boost brown fat and fight aging.

Signals can tell cells to act cancerous, surviving, growing and reproducing out of control. And signals can also tell cells with cancerous characteristics to stop growing or to die. In breast cancer, one tricky signal called TGF-beta does both – sometimes promoting tumors and sometimes suppressing them.

A study recently published in the journal Oncogene details how tumors may flip the TGF-beta signalling switch, allowing doctors to delete the pathway entirely when it promotes tumors, and leave it intact when it’s still working to suppress them.