Cancer Research

It's not often that cancer research gets compared to gridlock traffic in New York City but it makes some sense. If we are driving from Florida, we might take I-95 to get there, but if we are driving from California, we would take I-80. It's a matter of circumstance and then some variables based on choice.

John McDonald, a professor in the School of Biology at the Georgia Institute of Technology in Atlanta
, says that cancers also have lots of routes to get to the same disease and that assessing the route to cancer on a case-by-case basis might make more sense than the way it is done now.

A study led by Manchester scientists has shown promising results for a new treatment approach in follicular lymphoma.

Follicular lymphoma is a type of non-Hodgkin's lymphoma, a blood cancer, that usually develops slowly but the majority of patients are diagnosed when their disease is already at an advanced stage.

Recent improvements in treatment have included the use of antibodies to specifically target the tumour cells and to stimulate the patient's own immune system to attack their tumor. The use of such antibodies has improved treatment response, but unfortunately most patients still relapse. Radioimmunotherapy – where a radioactive substance is attached to the antibody – has been shown to be successful in treating patients who had previously relapsed. 

The precautionary principle says when it comes to health, you err on the side of caution, and a well-publicized effort to get annual screening for breast cancer paid off - but it hasn't lowered mortality rates in women aged 40-59. An annual physical examination does just fine, according to a 25-year study.

Military veterans exposed to the herbicide Agent Orange may be at higher risk for certain types of skin cancer, suggests a new report.

Agent Orange is a defoliant famously used by the British military during the Malayan Emergency and the U.S. military period of the Vietnam War.

The study adds to existing evidence that risk of non-melanotic invasive skin cancer (NMISC) is increased even four decades after Agent Orange exposure, with at least some exposed veterans having unusually aggressive non-melanoma skin cancers. 

Skin Cancers Present in About Half of Vets Exposed to Agent Orange

 A new whole-body, diffusion-weighted magnetic resonance imaging (MRI) scan could improve care for myeloma  - cancer of the white blood (plasma) cells, one of the most common forms of blood cancer - and reduce reliance on bone marrow biopsies, which can be painful for patients and often fail to show doctors how far the disease has spread. 

Whole-body, diffusion-weighted MRI scans showed the spread of cancer throughout the bone marrow of patients with myeloma more accurately than standard tests. The scans also showed whether the patients were responding to cancer treatments. 

The universe of cancer mutations just got a whole lot bigger.

By analyzing the genomes of thousands of patients' tumors, a research team has discovered many new cancer genes, expanding the list of known genes tied to these cancers by 25 percent. Moreover, the study shows that many key cancer genes still remain to be discovered. The team says that creating a comprehensive catalog of cancer genes for scores of cancer types is feasible with as few as 100,000 patient samples.

Researchers have sequenced the genome of the world's oldest continuously surviving cancer, a transmissible genital cancer which causes grotesque genital tumors in dogs around the world.

It first arose in a single dog that lived about 11,000 years ago and survived after the death of this dog by the transfer of its cancer cells to other dogs during mating and, from there, around the world.

A little studied chemical compound dubbed BMH-21 targets and shuts down a common cancer process in laboratory-grown human tumor cell lines.  BMH-21  disrupted tumor cell division and prevented growth of advanced cancer cells. 

Johns Hopkins researcher Marikki Laiho, M.D., Ph.D., and colleagues focused on the ability ofBMH-21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicate. Their research linked the pathway to p53 gene activity. P53 is a tumor suppressor gene, a protein that regulates cell growth, and it is the most frequently mutated suppressor gene in cancer.

A new review outlines the health effects of silica, and calls for action to reduce illness and death from silica exposure at work.

A team of researchers indicate that the peptide fragment
lactoferricin B25 (LFcinB25)
derived from cow's milk exhibited potent anti-cancer capability against human stomach cancer cell cultures.

They determine that LFcinB25 has potential to be a future therapeutic agent for gastric cancer.

Investigators evaluated the effects of three peptide fragments derived from lactoferricin B, a peptide in milk that has antimicrobial properties. Only one of the fragments, LFcinB25 reduced the survival of human AGS (Gastric Adenocarcinoma) cells in a dose-dependent and time-dependent manner.