Cancer Research

Human tumors grown in mouse models have long been used to test promising anti-cancer therapies. However, when a human tumor is transplanted into a mouse, the mouse immune system must be knocked down so that it doesn't attack the foreign tumor tissue, thus allowing the tumor to grow. A University of Colorado Cancer Center study describes a new model, XactMice, in which human blood stem cells are used to grow a "humanized" mouse immune system prior to tumor transplantation.

What makes triple negative breast cancer more lethal in African-American women than European-American ("White") women? A new study reveals specific genetic alterations that appears to impact their prognosis and ultimately survival rates.

Much of what we know about cancer and many modern medicines that treat it grow from experiments on cancer cells but it is difficult to maintain the integrity of cell lines due to contamination or simple mistakes such as mislabeling.

Later generations of a cell line may bear no resemblance to the original sample, potentially invalidating results of research performed on mistaken cells. For this reason, the National Cancer Institute maintains a library of 60 authenticated human cancer cell lines for the purposes of research, called the NCI-60.

We can complain about the cost of American health care but that is the price for doctors caring too much. While in Holland doctors can just unilaterally make the decision to let a patient die, in the United States doctors will continue to recommend tests even when recommendations are that they should be done half as often.

Obesity was associated with an increased risk for prostate cancer in African-American men and that risk grew by nearly four times as body-mass index (BMI) increased, according to a new study. 

African-American men have the highest incidence of prostate cancer of any racial or ethnic group in the United States, as well as the highest rates of aggressive disease and prostate cancer death. 

Cancer mortality remains significantly elevated among African-Americans but if recent trends continue, cancer outcomes will disappear over time, according to a new analysis of "Health Equity" - defined by the US Department of Health and Human Services as the highest level of health for all people.

Melanoma, an aggressive form of skin cancer, has been increasing in incidence in adults over the past 40 years.

Pediatric melanoma is rare (5 or 6 children per million) but some studies indicate that incidence has been increasing. A new study in The Journal of Pediatrics found that is not so, and the incidence of pediatric melanoma in the United States decreased from 2004-2010.

On one side of the political spectrum in America and across a broader swath of Europe, science is controversial - especially genetic engineering. But genetic engineering has been done since humans first deduced they could shape the natural world, if anything it has gotten precise in a way that was never possible before.

Now it mean even help fight against cancer - and it may do so using Salmonella, more famous as a bacteria that lives in intestines.

A vital self-destruct switch in cells is hijacked - making some pancreatic and non small cell lung cancers more aggressive, according to new research which found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells.

The research, carried out in cancer cells and mice, shows that in cancers with faulty versions of the KRAS gene these TRAIL receptors actually help the cancer cells to grow and spread to new areas in the body. These KRAS faults occur in 95 percent of pancreatic cancers - pancreatic ductal adenocarcinoma - and 30 percent of non small cell lung cancers.

Melanoma is the leading cause of skin cancer¬related deaths and surgical excision is the primary therapy for melanoma. It is recommended that melanomas should be excised within 4 to 6 weeks of the diagnostic biopsy because surgical delay may result in the potential for increased illness and death from other malignant neoplasms, along with anxiety and stress. 

In a study that included more than 32,000 cases of melanoma among Medicare patients, approximately 20 percent experienced a delay of surgery that was longer than 1.5 months, and about 8 percent of patients waited longer than 3 months for surgery.