Valium, one of the best known antianxiety drugs, produces its calming effects by binding with a particular protein in the brain. But the drug has an almost equally strong affinity for a completely different protein. Understanding this secondary interaction might offer clues about Valium's side effects and point the way to more effective drugs.

Tobacco use has plummeted in the past few decades, due to high taxes, bans on advertising and generous contracts for public relations companies to vilify smokers - but there are still more than a billion people worldwide who regularly use tobacco, including many who purchase the products illicitly.

Tens of thousands of pounds of methane leak per hour from equipment in three major natural gas basins that span Texas, Louisiana, Arkansas and Pennsylvania, according to airborne measurements published today. But the overall leak rate from those basins is only about one percent of gas production there--lower than leak rates measured in other gas fields, and in line with federal estimates.

Cancer vaccines are designed to turn the body's own immune system specifically against tumor cells. Particularly promising are vaccines that are directed against so-called neoantigens: These are proteins that have undergone a genetic mutation in tumor cells and, therefore, differ from their counterparts in healthy cells. The tiny alteration - sometimes only a single protein building block has been changed - gives the protein on the tumor cell surface novel immunological characteristics that can be recognized as "foreign" by the immune system's T cells. Therapeutic vaccines using a short protein fragment, or peptide, specifically containing the mutated site can then direct immune cells specifically to the tumor.

Potatoes are an essential food for humans and now two new varieties produced by the Basque Institute for Agricultural Research and Development have been added to the Registry of Commercial Varieties. 

Worldwide, consumption of healthy foods such as fruit and vegetables has improved during the past two decades, but has been outpaced by the increased intake of unhealthy foods including processed meat and sweetened drinks in most world regions, according to the first study to assess diet quality in 187 countries covering almost 4.5 billion adults, published in The Lancet Global Health journal.