A psychedelic drug, (R)-DOI, prevents the development of allergic asthma in a mouse model. The effects are potent and effective at a concentration 50-100 times less than would influence behavior.

In Manot, a karstic cave in the North of Israel close to the Lebanese border, excavations that began in 2010 have documented the peopling of the cave for over 100,000 years.

Around 30,000 years ago, the roof of the cave collapsed and sealed the archaeological layers until the 21st century. Beside stone tools and animal bones, some few human remains were preserved. The most spectacular finding was made on an elevated shelf within a small chamber of the cave: a very well preserved "calotte", the upper part of a braincase.

The facial bones which contain a lot of diagnostic traits were missing.

Amid the growing debate about the high price of powerful new drugs in the United States, a recent analysis suggests that breakthrough therapies for blood cancers may, in many cases and with some important caveats, provide reasonable value for money spent. Researchers present this viewpoint, based upon a comprehensive analysis of published cost-effectiveness ratios, online today in Blood, the Journal of the American Society of Hematology (ASH). The manuscript is being published as a Blood Forum article, a feature of the journal designed to present well-documented opinions on controversial topics and provide a sounding board for issues of importance to the science and practice of hematology.

A collaborative study led by scientists from the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) has revealed the mechanical forces that drive epithelial wound healing in the absence of cell supporting environment. This research was published in Nature Communications in January 2015.

Skin not only provides an essential protective barrier against foreign materials and pathogens, but it also helps the body retain various fluids and electrolytes. When this barrier is damaged, the consequences can be devastating. Ulcers, bleeding and bacterial infections may result and the chances of these occurring increases the longer wounds remain open.

A barrier to increased human papillomavirus (HPV) vaccination has been the concern that it may promote unsafe sexual activity, but a new study of adolescent girls finds that HPV vaccination was not associated with increases in sexually transmitted infections (STIs).

Both weight gain and weight loss in older (postmenopausal) women are associated with increased incidence of fracture, but at different anatomical sites, finds a study published in The BMJ this week.

The findings also challenge the traditional view that weight gain protects against fractures.

The influence of body weight on the risk of fracture is complex. Low body weight is a well recognised risk factor for fracture, but obesity also increases the risk of fracture at some sites. How fracture patterns differ after intentional and unintentional weight loss in postmenopausal women is also unknown.