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Melville on Science vs. Creation Myth

From Melville's under-appreciated Mardi: On a quest for his missing love Yillah, an AWOL sailor...

Non-coding DNA Function... Surprising?

The existence of functional, non-protein-coding DNA is all too frequently portrayed as a great...

Yep, This Should Get You Fired

An Ohio 8th-grade creationist science teacher with a habit of branding crosses on his students'...

No, There Are No Alien Bar Codes In Our Genomes

Even for a physicist, this is bad: Larry Moran, in preparation for the appropriate dose of ridicule...

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Michael WhiteRSS Feed of this column.

Welcome to Adaptive Complexity, where I write about genomics, systems biology, evolution, and the connection between science and literature, government, and society.

I'm a biochemist

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Today's issue of Molecular Cell has two complementary papers on biological signal processing that look interesting (subscription required): "The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation":
Back in August, I gave a talk at the Pacific AAAS meeting explaining why research scientists need to blog. After a long delay to put my incomprehensible notes in to readable (but still somewhat fragmented) form, here is my argument for why scientists need to blog:

Expert Blogging in the Science Communication Ecosystem

My talk is about scientists writing science directly for the public. Specifically, I want to get at the question, "What can blogging by scientists bring to the science communication ecosystem of newspapers, TV, and magazines?"

Via Chris Mooney, I learn that Rush Limbaugh, whose ability to smell out a conspiracy is on par with the ability of the male silk moth to sniff out the presence of a female from miles away, has called the whole H1N1 thing a hoax:
What's the relationship between soy consumption and breast cancer? Some major news from JAMA:

The scientist has a lot of experience with ignorance and doubt and uncertainty, and this experience is of very great importance, I think. When a scientist doesn’t know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty darn sure of what the result is going to be, he is still in some doubt. We have found it of paramount importance that in order to progress, we must recognize our ignorance and leave room for doubt.

- Richard Feynman, What Do You Care What Other People Think?, p. 245


Men are born soft and supple;
dead they are stiff and hard.
Plants are born tender and pliant;
dead they are brittle and dry.

Molecular biologists and mathematical models frequently don't mix well, especially when the molecular biologists in question were trained before the rise of genomics, back when most labs only needed a computer for designing new vector sequences, writing papers, and checking email. Behind this skepticism is the intuition that biology is extremely messy (true), and difficult to quantify (also true). Also contributing is the long history of the cell as a molecular black box; for a long time, we had no idea what was going on inside the cell in molecular terms (somewhat analogous to doing chemistry without knowing about atoms), and in fact we still don't know the molecular role of a good chunk of the protein-coding genes in the human genome.