A major study of the organization and regulation of the human genome published today changes our concept of how our genome works. The integrated study is an exhaustive analysis of 1% of the genome that, for the first time, gives an extensive view of genetic activity alongside the cellular machinery that allows DNA to be read and replicated.
The lead report from the ENCyclopedia Of DNA Elements (ENCODE) Consortium, published in Nature, together with 28 companion papers published in Genome Research, defined in detail which regions of the genome are actively copied in the cell, revealed the location and studied evolution of elements that control gene activity, and defined the relationship between DNA-associated proteins and gene activity and DNA replication.