Experts present an analysis of long term data on the success of stem cell transplantation for osteopetrosis patients which suggests second transplants should be considered a key option.

The unique cooperation model used in the political field by the countries around the Baltic Sea needs to be extended to the public-private sector in order to increase the competitiveness and attractiveness of the Baltic Sea Region. This was one of the main conclusions reached by the leading representatives from business, government and research within the ICT and Life-Science at the seminar "Talents on Top of Europe" at the Nordic Embassies in Berlin today.

When the activity of individual genes it is longer required, there are two main mechanisms responsible for the “switching off”, mainly DNA methylation and the Polycomb protein complex.

Sometimes, these mechanisms lose their efficiency and some of the genes that should be “switched off” remain active. This, in turn, could lead to uncontrolled cellular proliferation, and tumorigenesis. These mechanisms, present both in lower organisms as well as in mammals, have always been thought to be separated and independent.

Dr. Peter K. Gregersen says he has finally closed the circle between key genes and more than a 1,000 patients with rheumatoid arthritis. The genes will help tell the story of how the immune system works to create specific antibodies that in turn increase a person’s risk for this crippling disease.

Gregersen's group conducted genome-wide scans to identify polymorphisms, or genetic variants, that are associated with the inflammatory condition and can be used to understand the triggers of the disease. This will provide key insights into the pathways underlying rheumatoid arthritis and other autoimmune diseases. It may ultimately provide tests to predict who will respond to the available new treatments.

Logic or feeling. Left-brained or right-brained. The terms have become part of the lexicon for categorizing intellectual and artistic people. It turns out there may be more than just wishful thinking in labelling people. New research has furthered our understanding of the different roles of the left and right sides of our brains.

A study led by the University of Exeter has highlighted differences in the ability of people to perform basic tasks, depending on whether the left or right sides of their brains have been damaged by a stroke. The research identified the role of the right side of the brain in noticing and correcting errors.

A simple, cheap treatment using just oxygen could allow growers to store organic produce for longer and go a long way towards reducing the price of organic fruit and vegetables.

Currently UK shoppers have to pay twice as much for some organic products. Organic apples, for example, are around double the price of conventionally grown apples in Sainbury’s, Waitrose and Tesco.

Northwestern University researchers have discovered a drug that slows – and may even halt – the progression of Parkinson’s disease. The drug rejuvenates aging dopamine cells, whose death in the brain causes the symptoms of this devastating and widespread disease.

D. James Surmeier and his team of researchers have found that isradipine, a drug widely used for hypertension and stroke, restores stressed-out dopamine neurons to their vigorous younger selves.

An international study by researchers at Seattle Children’s Hospital Research Institute, the University of Washington School of Medicine, and Radboud University in Nijmegen, Netherlands has identified a new genetic cause for Joubert syndrome (JS).

Joubert syndrome is an inherited condition that affects development of the cerebellum and brainstem, the structures in the brain that coordinate movements and regulate basic functions such as breathing, swallowing, heart rate and consciousness. The study confirms key information about the genetic changes that cause JS and cellular structures called cilia, conclusively placing JS in a class of recently identified ciliopathic conditions.

More than 26 million people worldwide were estimated to be living with Alzheimer’s disease in 2006, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

The researchers also concluded the global prevalence of Alzheimer’s disease will grow to more than 106 million by 2050. By that time, 43 percent of those with Alzheimer’s disease will need high-level care, equivalent to that of a nursing home.

We've all had the feeling we've been somewhere before or had a feeling we've previously had a conversation. It isn't magic or mysticism, the answer is in a set of neurons called your 'place cells.'

Researchers believe these 'place cells' fire to provide a sort of blueprint for any new space we encounter. The next time we see the space, those same neurons fire. Thus we know when we've been somewhere before and don't have to relearn our way around familiar turf. But similar spaces may activate overlapping neuronal blueprints, leaving room for confusion if the neurons are not fine-tuned. Thus happens deja vu.


Source: University of Bristol