Researchers were able to controll seizures in epileptic mice with a one-time transplantation of medial ganglionic eminence (MGE) cells into the hippocampus, which inhibit signaling in overactive nerve circuits.
Cell therapy has become a focus of epilepsy research, in part because current medications, even when effective, only control symptoms and not underlying causes of the disease, according to Scott C. Baraban, PhD of UC San Francisco, who led the new study. In many types of epilepsy, he said, current drugs have no therapeutic value at all.