The U.S. Defense Advanced Research Projects Agency (DARPA) is funding basic research on non-genetic drugs that can temporarily enhance the human body’s ability to endure extreme cold exposure.

The human body’s response to cold involves two biological processes known as thermogenesis. Shivering is something everyone has experienced, it raises your body temperature in a direct fashion, with movement. The second uses brown adipose tissue, brown fat, which regulates body temperature by breaking down blood sugar and other fat molecules  The first is physical and the second chemical, but the second happens first. It just doesn't generate as much heat.

Since 1975, stroke mortality plummeted from 88 to 31 per 100,0000 for women and 112 to 39 per 100,0000 for men, but since 2020 it has been creeping back up. 

Strokes haven't seen a huge resurgence yet because Baby Boomers, and soon Generation X, have the biggest risk for it like aging is for most diseases. For example, a 10 percent reduction in the fatality rate for 75-year-olds would more than offset a doubling of the fatality rate among 35-year-olds because strokes are 100 times more common in 75-year-olds. Yet that Millennials are seeing higher numbers than previous generations at their ages is a concern.

Phase 2 data showing a reduction in amyloid-beta plaques in early Alzheimer's patients is good enough for FDA to give it temporary approval under their Accelerated Approval pathway.

The positive results occurred in mild cognitive impairment or mild dementia patients. Lecanemab-irmb is a 100 mg/mL injection for intravenous use, a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble (“protofibril”) and insoluble forms of amyloid beta (Aβ) for the treatment of Alzheimer’s disease (AD). The approval is based on Phase 2 data that demonstrated that LEQEMBI reduced the accumulation of Aβ plaque in the brain, a defining feature of Alzheimer's Disease.

Going to an area where there are a lot of wind vanes can be shocking. The noise and environmental blight for so little energy isn't worthwhile, and needing to get exemptions from endangered species laws due to deaths of avians like eagles make them a real negative.

Solar panels have a little better cultural response but can still be unattractive. If you are a wealthy elite who doesn't like the appearance, or a government building using taxpayer funds, you may be able to turn architectural constraints into alternative energy without ruining the aesthetic. The archaeological park of Pompeii and the Portuguese city of Evora are creating solar panels that look like ancient Roman tiles or terracotta bricks to match the skyline.

Inscriptions on the walls and crosses in a grotto first found by grave robbers in Lachish national park of the Judean lowlands west of Jerusalem have led archaeologists to conclude it was dedicated to Salome, associated with the birth of Jesus Christ in early Christian accounts.  The Jewish burial chamber and ossuaries dating back to the Roman period became part of a Christian chapel during the Byzantine era until the region was captured by the Rashidun Caliphate in the middle of the 7th century.

From insulin to lowering environmental strain to grow food, genetic engineering is one of the marvels of the 20th century. In the 21st, CRISPR-Cas9 or something else may achieve the same lofty status but genetic engineering isn't done yet.