Why Both Stimulating And Blocking GLP-1R Helps People Lose Weight
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Understanding which brain circuits respond to weight loss medications and how they behave could lead to better weight loss with fewer side effects.
Scientists have long struggled to figure out how the brain guides the complex movement of our limbs, from the graceful leaps of ballerinas to the simple, everyday act of picking up a cup of coffee. Using tools from robotics and neuroscience, two Johns Hopkins University researchers have found some tantalizing clues in an unlikely mode of motion: the undulations of tropical fish.
The fish is a glass knifefish, which was used in the research. It is native to South America.
Photo by Will Kirk/HIPS
Malaria kills more than one million people each year, most of them young children living in Africa. Now physicists in the UK have shared their computers with biologists from countries including France and Korea in an effort to combat the disease.
Using an international computing Grid spanning 27 countries, scientists on the WISDOM project analysed an average of 80,000 possible drug compounds against malaria every hour. In total, the challenge processed over 140 million compounds, with a UK physics Grid providing nearly half of the computing hours used.
The computers are all part of EGEE (Enabling Grids for E-sciencE), which brings together computing Grids from different countries and disciplines.
Groundhogs and other hibernators take a very sensible approach to winter: They slip into a state of suspended animation and let the worst of the cold weather pass.
The cold prompts profound physiological changes in these animals, causing their normally fast metabolism to come almost to a stop during winter. With metabolism slowed to a crawl, the animal draws on its fat stores sparingly to make it through the winter.
Hibernation has become the focus of interesting physiological research. A hibernating squirrel's heart may fall from 300 beats per minute to just three per minute. Its oxygen consumption can drop to just 2% of normal.
Tricking a key enzyme can soothe over-excited receptors in the brain, say neuroscientists, calling this a possible strategy against stroke, Alzheimer's and other neurodegenerative diseases.
Lead author Michel Baudry of the University of Southern California, his graduate student Wei Xu and collaborators from the University of British Columbia outline their technique in the Feb. 1 issue of Neuron.
The researchers injected laboratory mice with a decoy peptide containing a snippet of a receptor that facilitates cell death in neurodegenerative diseases.
British Petroleum announced today that it has selected the University of California, Berkeley, in partnership with Lawrence Berkeley National Laboratory (LBNL) and the University of Illinois at Urbana-Champaign, to lead an unprecedented $500 million research effort to develop new sources of energy and reduce the impact of energy consumption on the environment.
The funding will create the Energy Biosciences Institute (EBI), which initially will focus its research on biotechnology to produce biofuels — that is, turning plants and plant materials, including corn, field waste, switchgrass and algae, into transportation fuels.
At a press conference this morning at UC Berkeley, Robert A. (Bob) Malone, chairman and president of BP America Inc., joined California Gov.
"Time" is the most popular noun in the English language, yet how would we tell time if we didn't have access to the plethora of watches, clocks and cell phones at our disposal?
For decades, scientists have believed that the brain possesses an internal clock that allows it to keep track of time. Now a UCLA study in the Feb. 1 edition of Neuron proposes a new model in which a series of physical changes to the brain's cells helps the organ to monitor the passage of time.
The changing colors reflect how a brain cell network evolves over time in response to stimuli. (Credit: Buonomano Lab)
Assistant Professor John Howell and his Quantum Optics team at the University of Rochester have discovered a way to manipulate a light field while retaining all of the information it carries. A considerable advance in imaging technology, the new method detects subtle changes in an image over time. Using photons and atomic vapor in what is known as imaging with slow light, the new technique precisely slows the image while retaining all of its properties.
The basic setup of the experiment is a single light source (a laser), a single camera (feeding to a computer) for observation, and between them, a path for the laser beam.
As humans exert ever-greater influence on the Earth, their preferences will play a substantial role in determining which other species survive.
Instead of dismissing grumblings about being tired or exhausted, people should take these complaints seriously before they lead to a worsened health state or even death, says a University of Alberta researcher investigating fatigue.
Dr. Karin Olson, a U of A professor from the Faculty of Nursing, argues that there are differences between tiredness, fatigue and exhaustion and that recognizing those distinctions will help health-care workers create better treatment plans for their patients.
Sitting down to a family meal more often and cutting down on television watching can help keep children from becoming overweight, according to a new University of Missouri-Columbia study.
After following 8,000 children from kindergarten to third grade, researchers concluded that kids who watched the most TV were at the greatest risk of being or becoming overweight. Children who ate fewer meals with their families also were at risk for becoming overweight.
Common sense used to be more common
The House Appropriations Committee has passed its version of the 2007 federal government budget. In it, funding for NASA was cut by $550 million (approximately 3.2%) from the amount proposed by the Bush Administration last February.
S.O.S. Save Our Science Campaign Button. Credit: The Planetary Society
Heartbeat and breathing cycles can become synchronized, a new study shows.
Looking for patterns in the sequence of human heartbeats is a much studied subject; evidence for pattern-revealing characteristics such as chaos and fractal or spiral geometry have been sought. Breathing, which is more under direct conscious control than heartbeat, is much less studied.
Ayurvedic Yoga uses a synchronized breathing/heartbeat system