MiR-25 Shuts Down The Overworked Heart

Cardiovascular disease often causes the heart to work harder than usual, a condition that triggers...

MicroRNA- The Unexpected Pain Neurotransmitter

Since the discovery of microRNAs, these small ribonucleotides have been implicated in a broad range...

How Presenilin Mutations Destroy Memories

Memory loss is a debilitating consequence of dementia such as Alzheimer’s disease (AD), an incurable...

Turning Off The Extra Chromosome In Down Syndrome

Gleaning from the natural process of X chromosome inactivation, scientists recently discovered...

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Jennifer WongRSS Feed of this column.

My column covers the latest primary research discoveries in the life-science discipline. Much of what is reported here are considered discoveries that I think are the most significant and far-reaching... Read More »


While there are many proposed “magic bullets” since the 1940s to combat cancer, more than 90% of these drug candidates fail during clinical trials.

Part of the reason for this failure is because many drugs are often effective in eliminating only the bulk of the tumor without even touching the root of the disease. With the discovery of cancer stem cells as the root of cancer in the 1970s, scientists began developing therapeutics against cancer stem cells with hopes to eliminate cancer for good.

In light of ethical concerns with using human embryonic stem (hES) cells for research and therapeutic development, scientists have since developed technologies to allow one to reprogram somatic cells into pluripotent stem cells that are akin to hES cells.
Macular teleangiectasia (MacTel) is a progressive idiopathic form of retinal degeneration that occurs in adulthood, and is caused by a number of factors including diabetic retinopathy, hypertension, venous occlusion, inflammatory diseases, and blood disorders (Yannuzzi et al., 2006) (Shen et al J Neurosci 32:15715-15727).

Studies by Ding et al (Cell 2012) revealed that telomerase dysfunction early in disease onset creates genomic aberrations crucial for telomerase-driven prostate cancer metastasis into the lumbar spine.

Live imaging technology is becoming an increasing popular tool to visualize real-time cellular events in the tumor microenvironment during metastatic progression.