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    Don't Ghettoize Innovation
    By Michael White | November 30th 2009 01:30 PM | 6 comments | Print | E-mail | Track Comments
    About Michael

    Welcome to Adaptive Complexity, where I write about genomics, systems biology, evolution, and the connection between science and literature,

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    This isn't news anymore (see here, and here), but Bruce Alberts, Editor-in-Chief of Science has weighed in on the out-of-whack system of incentives in the biomedical sciences:

    Assuming that the system supporting this career path works well, these will be the individuals with the most talent and interest in such an endeavor: young people well positioned to make the scientific breakthroughs that societies need to survive and thrive. But the current system squanders the creativity and energy of these exceptionally gifted young people through a funding process that forces them to avoid risk-taking and innovation.

    The traditional peer review system on which scientists depend for federal grant support values biomedical research projects that are almost certain to "work," encouraging young scientists to pursue a narrow range of projects that closely follow the proven paths of their mentors. As a result, many scientists pursue identical research ideas, creating a competition to finish and publish that can value speed over quality. Worse, the innovation that is essential for keeping science exciting and productive is replaced by a great deal of "me-too" science: research that has little chance of producing the breakthroughs needed to improve human health.


    Alberts adds one more dimension to the discussion: he criticizes the NIH's special innovator awards, designed to encourage less conventional projects, as being too little to have much effect on the culture of the biomedical sciences.

    And he's right - why should bolder, higher-risk/higher payoff proposals be ghettoized to their own funding mechanism, one with a success rate that is 10 times lower than that of the R01 mechanism? As a new investigator, right now you have a choice: go with an unimaginative, conventional project that will, with a reasonably high probability, after a >1-year processes get you an R01, or put your grant-writing energy into an extremely creative idea that has only a 1% chance of getting funded. (Alberts writes that in a recent round, there were 2200 applications for 30 NIH Director's New Innovator Awards.)

    Alberts suggests that we bump the number of these awards from 30-50 up to 500. I don't think that's enough. We need to overhaul the way bread-and-butter R01's get evaluated, so that near-certain feasibility is not the top criterion for funding.


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    Comments

    Andrea Kuszewski
    I love that word, 'ghettoize'. I thought I was the only one that used it. Good stuff. (^_^)
    Andrea Kuszewski
    By the way, I cannot say this enough.... We need to recognize, value, and support creativity and innovation in the sciences, and not squelch it whenever it dares to peek out!
    Mark Changizi
    Nice blog, Michael. My sentiments exactly.
    Excellent points. Of course, when we had a thriving venture capital market, talented researchers with a entrepreneurial bent had an alternative to NIH, NSF, etc. Unfortunately, since 2000 we have passed a number of laws and regulations that are killing innovation in the US. The incredible innovation of the 90s was based on technology start-up companies built on intellectual capital, financial capital, and human capital. All three of the pillars have been under attack since 2000. Our patent laws have been weakened reducing the value of intellectual capital. Sarbanes Oxley has made it impossible to go public reducing financial capital for start-ups and the FASB rules on stock options have made it harder to attract human capital to start-ups. My forthcoming book The Decline and Fall of the American Entrepreneur: How Little Known Laws and Regulations are Killing Innovation, explains these problems in more detail. For a preview see http://hallingblog.com/my-forthcoming-book-1209/

    In addition, a thriving secondary market for patents would allow researchers who did not have an entrepreneurial bent, could also profit, receive funding for research, and avoid the federal funding dilemma. For more information on how to create a secondary market for patents see http://hallingblog.com/2009/11/16/jump-starting-a-secondary-market-for-p....

    adaptivecomplexity
    It's so stifling. Like it or not, the NIH is the biggest source of funding out there. Unless you're an HHMI investigator, it's extremely tough to run a biomedical lab on non-NIH funding - the money just isn't there to the same degree. And so the NIH dominates the scientific culture.
    Mike
    I love your article

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