Screening is underway to find a patient for the world's first bladder transplant in humans. 

A revolution is taking place, but we seem to not yet realize it. 
Paradigm shifting technologies often produce an abrupt transition when they get adopted. However, that transition is not easy to recognize early on: the effects of an exponential trend appear linear at the begninning, so the explosive force of the transition that occurs a little later takes many by surprise.

Prior to natural gas hydraulic fracturing making played out gas wells viable again, America was in a real climate emissions pickle. In 1994, Democrats finally won their war of extinction on nuclear energy, they cheered as President Bill Clinton and Senator John Kerry(1) created regulations that act as bans and eventually forced through a series of anti-nuclear activists at the head of the Nuclear Regulatory Commission.

For years, many have feared that artificial intelligence (AI) will take over national security mechanisms, leading to human slavery, domination of human society and perhaps the annihilation of humans. One way of killing humans is medical misdiagnosis, so it seems reasonable to examine the performance of ChatGPT, the AI chatbot that is taking the world by storm. This is timely in light of ChatGPT’s recent remarkable performance in passing the US medical licensing exam.

Many women eat healthier during pregnancy, but that may mean whatever version of 'healthy' is trending in any given year. Sugar-free, low-fat, gluten-free, paleo, organic, it all has proponents, it all has suspect epidemiology papers claiming it should be a reason to buy some New York Times bestselling diet book built around it.

If a vaccine requires cold storage for shipping, many areas where infrastructure doesn't hold up are unable to receive them. A possible solution to this problem is a mobile vaccine printer that could produce hundreds of vaccine doses in a day.

The printer produces patches with hundreds of microneedles containing the vaccine. The patches can be attached to the skin, allowing the vaccine to dissolve without the need for a traditional injection. Once printed, the vaccine patches can be stored for months at room temperature.

In their paper, the scientists used the printer to produce thermostable Covid-19 RNA vaccines that could induce a comparable immune response to that generated by injected RNA vaccines, in mice.

Today I am traveling to Banff, a pleasant mountain resort in western Canada, to attend a workshop on systematic uncertainties. Yes, you heard that right - a bunch of physicists and statisticians will be gathering in a secluded location for a whole week, with the sole purpose of debating on that exotic topic. How weird is that? I bet most of you don't think much of systematic uncertainties. What are they, anyway?

Known unknowns

In 2016, The Frank R. Lautenberg Chemical Safety for the 21st Century Act amended the Toxic Substances Control Act (TSCA) and created a mandatory requirement for EPA to evaluate existing chemicals using transparent methodology and risk-based assessment. Not simplistic epidemiology.

This was actually a good thing. We want to make sure people are still safe as new data arrive and since they were using science and not statistical correlation, we could have confidence in the results.

The International Agency for Research on Cancer (IARC), a United Nations epidemiology group headquartered in France, could be in ethical hot water again over the claim by a Ramazzini Institute leader that seems to know in advance that IARC will consider aspartame a carcinogen - a designation which leads to automatic warning labels or even bans in places like California, which under Proposition 65 turned over its science to IARC last century.

Alcohol is a legitimate class 1 carcinogen that is prized by most of the world. While claims of health benefits were always suspect epidemiology, so were claims that even a glass of wine during pregnancy would cause birth defects. The dose still makes the poison but as modern science journalism became more advocacy-driven, claims that any dose is probably a poison became common.