Clinical Research

Doctors at the University of Arizona Cancer Center at St. Joseph's Hospital and Medical Center in Phoenix report  in Lancet Oncology that a new treatment for ovarian cancer can improve response rates (increase the rate of tumor shrinkage) and prolong the time until cancers recur.  

Trebananib (formally known as AMG 386; Amgen) is a first-in-class peptide-Fc fusion protein (or peptibody) that targets angiogenesis (the growth of new blood vessels into cancerous tumors) by inhibiting the binding of both angiopoietin 1 and 2 to the Tie2 receptor.

This is a different mechanism of action than other agents that also effect angiogenesis by inhibiting vascular endothelial growth factor (VEGF) such as bevacizumab (Avastin; Genentech).  


Bellerophon Therapeutics has completed enrollment of its 80-patient Phase 2 clinical trial of INOpulse for the treatment of pulmonary arterial hypertension (PAH). PAH is a life-threatening, progressive disorder characterized by abnormal constriction of the arteries of the lung, leading to increased blood pressure in the lungs and abnormal strain on the heart's right ventricle, eventually leading to heart failure.  
Amgen announced that it will collaborate with the National Cancer Institute and other public and private sector partners on the Lung Master Protocol (Lung-MAP), a clinical trial program that will use biomarker-driven research and genomic profiling to match squamous cell lung cancer patients to investigational treatments based on their individual cancer profiles.

In humans, no therapy for  amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease,  has ever been discovered that could extend lifespan more than a few additional months.

ALS was first identified as a progressive and fatal neurodegenerative disease in the late 1800s but only gained international recognition in 1939 when it was diagnosed in American baseball legend Lou Gehrig. It's known to be caused by motor neurons in the spinal cord deteriorating and dying, and has been traced to mutations in copper, zinc superoxide dismutase, or SOD1. Ordinarily, superoxide dismutase is an antioxidant whose proper function is essential to life.


Individuals who are hospitalized for the skin conditions of Stevens-Johnson syndrome and toxic epidermal necrolysis appear to have a high risk of recurrence, according to a new study.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening conditions that develop primarily as responses to drugs, and result in extensive epidermal detachment (upper layers of the skin detach from the lower layers). Recurrence has been reported in isolated cases, and the overall risk of recurrence has been unknown, according to background information in the article.

Wine was once okay for pregnant women in moderation, then all alcohol was bad, then wine was good again because of the miracle product du jour,  resveratrol , but now it may be bad again.

A new research says that when taken during pregnancy, resveratrol supplements led to developmental abnormalities in the fetal pancreas. Resveratrol has been touted for its human health benefits for years and is readily available over the counter.


Can you predict how sensitive your sense of taste is by sticking your tongue out and counting the bumps?

A long-standing hypothesis says this is so. But a little crowdsourcing of science - what used to be called doing a study - disproved that idea that "supertasters" owe their special sensitivity to bitter tastes to an usually high density of taste buds on their tongue, according to a paper in Frontiers in Integrative Neuroscience.


Defensive medicine, to prevent malpractice claims, are far higher costs than medical personnel, but the United States shift to government health care is going to add a third component. Tests will be free and people will demand them.

Dr. Alai Tan, a senior biostatistician in the University of Texas Medical Branch at Galveston   Sealy Center on Aging and lead author of a new study has concluded that providing better access to health care may lead to the overuse of mammograms for women who regularly see a primary care physician and who have a limited life expectancy.

Screening women in this category could subject them "to greater risks of physical, emotional and economic suffering" but it could happen anyway.  


Children with bronchiolitis (a common respiratory tract infection that can result in hospitalization) who were treated in the emergency department showed less clinical improvement after receiving nebulized 3 percent hypertonic saline (HS) than infants who received normal saline (NS).  

Nebulized HS has been shown to increase mucociliary clearance (the clearing of mucus) in healthy people and in those patients with conditions such as asthma and cystic fibrosis because it is believed to lower the viscosity of mucus secretions. Other studies have suggested HS may reduce the length of hospital stays and lessen severity in children with bronchiolitis.


You've really got to hand it to all those 15-minute oil change places that dot the American landscape: they know how to pull motorists in.

With their brightly colored signs and endless promotions, it’s no wonder they succeed in getting our business. Whether you’re driving a brand new sports car or sedan with 200,000 miles on it, you’re welcome to drive up, get fresh oil and drive away...no problem.

But when it comes to bone marrow transplants, the sobering fact is that the age of the vehicle —in this case, your body — does matter.