Clinical Research

Gastric bypass surgery has become one of the most commonly performed procedures in the treatment of obesity. In most patients, it quickly produces substantial body weight loss and improved glucose tolerance. However, the metabolic improvements vary considerably from patient to patient.

A hormone test may be able to predict the extent of metabolic improvement caused by the gastric bypass. These are the results of a study on a rodent model conducted by Prof. Dr. Matthias Tschöp and his colleagues from the Institute of Diabetes and Obesity (IDO), Helmholtz Diabetes Center at Helmholtz Zentrum München together with a team of researchers led by Dr. Kirk Habegger at the Metabolic Disease Institute of the University of Cincinnati.


Despite what you may have read in the New York Times and other mainstream media outlets jumping on the 'sugar is bad' fad, sugar intake is off the hook in one area; nonalcoholic fatty liver disease. High-calorie diets promote the progression of this serious form of liver disease, but that isn't a sugar issue, it is a behavioral one.


Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health.


A new paper has found a significant association between low dietary fiber intake and cardiometabolic risks including metabolic syndrome, cardiovascular inflammation, and obesity.

 In the study, investigators used surveillance data from 23,168 subjects in the National Health and Nutrition Examination Survey (NHANES) 1999-2010  to examine the role dietary fiber plays in heart health, coupled with possible sex, age, racial/ethnic, and socioeconomic disparities in dietary fiber consumption. They also examined the association between dietary fiber intake and various cardiometabolic risk factors.


A new paper suggests that lifestyle advice for people with diabetes should be no different from that for the general public - but diabetes may benefit more from that same advice. 

In the study, the researchers investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes.


Grey literature in medicine has some valuable insight, according to a new paper. The authors say that clinical trial outcomes are more complete in unpublished reports than in publicly available information.

The results found that publicly available information contained less information about both the benefits and potential harms of an intervention than unpublished data. These findings highlight the importance of recent initiatives, such as the AllTrials initiative, that aim to make clinical trial outcome data publicly available, in order to provide complete and transparent information to help patients and clinicians reach decisions about clinical care.


A study to see whether narrowing of the veins from the brain to the heart could be a cause of multiple sclerosis has found that the condition is just as prevalent in people without the disease.

The results call into question a controversial theory that MS is associated with a disorder proponents call chronic cerebrospinal venous insufficiency (CCSVI).


A new paper details how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics, the mechanistic basis for how the MRSA bacterium became such a difficult pathogen over the previous 50 years, in which time it spread rapidly across the world.

MRSA has been a difficult hospital pathogen to control and has emerged in the broader community in the past several years, especially in such places as prisons, locker rooms and nurseries. In the United States alone, the disease infects about 100,000 people and claims the lives of nearly 20,000 people annually.



The first Phase II study to investigate the use of the anti-cancer drug, everolimus, for the initial treatment of advanced papillary kidney cancer has shown that it is successful in slowing or preventing the spread of the disease, according to research to be presented today (Sunday) at the 2013 European Cancer Congress (ECC2013) [1].