Researchers have developed a new method of repairing bone using a synthetic bone graft substitute material. Combined with gene therapy, they say it can mimic real bone tissue and has potential to regenerate bone in patients who have lost large areas of bone from disease or trauma.

The researchers have developed a scaffold material made from collagen and nano-sized particles of hydroxyapatite which acts as a frame for the body’s own cells and repairs bone in the damaged area using gene therapy. The cells are tricked into overproducing bone producing BMPs (proteins), encouraging regrowth of healthy bone tissue. 

A new study shows that supplementation with an encapsulated fruit and vegetable juice concentrate (Juice Plus+® Orchard Blend and Garden Blend) was associated with an increase in serum beta-carotene concentrations, reduced abdominal adipose tissue and improved insulin resistance in overweight boys compared to the placebo group. These study results add to the existing body of research about the role of nutrition in promoting children's health.

A new study has found that individuals taking cholesterol-lowering statin drugs are more likely than non-users to experience decreased energy, fatigue upon exertion, or both. The researchers suggest that these findings should be taken into account by doctors when weighing risk versus benefit in prescribing statins. 

Statins are among the most widely used prescription drugs on the market and therefore increased attention has focused on statins' side effects, particularly their effect on exercise. While some patients have reported fatigue or exercise intolerance when placed on statins, randomized trials had not previously addressed the occurrence of fatigue-with-exertion or impaired energy in patients on statins relative to placebo. 

A team of Australian scientists has identified new genes that show identifiable changes in the blood of people with bowel cancer.

The discovery has the potential to underpin a new cost-effective blood test that would signal the early stages of bowel cancer. This test could potentially save thousands of lives by supplementing existing screening programs and encouraging those at risk to have a colonoscopy.

The research presented today is the result of over five years of scientific collaboration between Australian biotechnology company Clinical Genomics, CSIRO and the Flinders Centre for Innovation in Cancer at Flinders University in Adelaide, lead by senior investigator Professor Graeme Young.

Clinical studies, the central means by which preventive, diagnostic, and therapeutic strategies are evaluated,  that were registered between 2007-2010 were dominated by small, single-center trials and contained significant heterogeneity (different in nature, difficult to compare) in methodological approaches, including the use of randomization, blinding, and data monitoring committees, according to an analysis in JAMA. 

A Cedars-Sinai Heart Institute clinical trial showed that treating heart attack patients with an infusion of their own heart-derived cells helps damaged hearts re-grow healthy muscle.  Patients who underwent the stem cell procedure demonstrated a significant reduction in the size of the scar left on the heart muscle by a heart attack. Patients also experienced a sizable increase in healthy heart muscle following the experimental stem cell treatments. 

Should researchers be obligated to publish null results?  Should they have to publish all trial data? Missing data distorts the scientific record, so that clinical decisions cannot be based on the best evidence, and that can harm patients and lead to futile costs to health systems, accoding to an editorial at BMJ.

It's no secret that a large proportion of evidence from human trials is unreported, and much of what is reported is done so inadequately but there is no real accounting for the consequences of unpublished evidence.