Clinical Research

Chicago – Jose Augusto Barreto-Filho, M.D., Ph.D., of the Federal University of Sergipe and the Clinica e Hospital Sao Lucas, Sergipe, Brazil, and colleagues assessed procedure rates and outcomes of surgical aortic valve replacement (AVR) among 82,755,924 Medicare fee-for-service beneficiaries between 1999 and 2011.


In 2008, an estimated 500,000,000 people were obese globally, which could result in a 2-4 year shorter life span, which increases to 8-10 years in those morbidly obese. Obesity is also a risk factor for adverse pregnancy and perinatal outcomes (relating to the time immediately before and after birth). 

Weight reduction is imperative to improve maternal health and bariatric surgery (the branch of medicine that deals with the causes, prevention, and treatment of obesity) is currently the most effective method. Its use has increased rapidly since the 1990s.


A paper in BMJ says that women with a history of obesity surgery are at increased risk of giving birth to preterm or small-for-gestational age babies and should be regarded as an at-risk group. 

Type 2 diabetes brings with it a long list of complementary issues: vascular and heart disease, eye problems, nerve damage, kidney disease, hearing problems and Alzheimer's disease.

A new study in the Journal of Bone and Mineral Research adds skeletal problems to that list, namely osteoporosis.


Gastric bypass surgery has become one of the most commonly performed procedures in the treatment of obesity. In most patients, it quickly produces substantial body weight loss and improved glucose tolerance. However, the metabolic improvements vary considerably from patient to patient.

A hormone test may be able to predict the extent of metabolic improvement caused by the gastric bypass. These are the results of a study on a rodent model conducted by Prof. Dr. Matthias Tschöp and his colleagues from the Institute of Diabetes and Obesity (IDO), Helmholtz Diabetes Center at Helmholtz Zentrum München together with a team of researchers led by Dr. Kirk Habegger at the Metabolic Disease Institute of the University of Cincinnati.


Despite what you may have read in the New York Times and other mainstream media outlets jumping on the 'sugar is bad' fad, sugar intake is off the hook in one area; nonalcoholic fatty liver disease. High-calorie diets promote the progression of this serious form of liver disease, but that isn't a sugar issue, it is a behavioral one.


Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health.


A new paper has found a significant association between low dietary fiber intake and cardiometabolic risks including metabolic syndrome, cardiovascular inflammation, and obesity.

 In the study, investigators used surveillance data from 23,168 subjects in the National Health and Nutrition Examination Survey (NHANES) 1999-2010  to examine the role dietary fiber plays in heart health, coupled with possible sex, age, racial/ethnic, and socioeconomic disparities in dietary fiber consumption. They also examined the association between dietary fiber intake and various cardiometabolic risk factors.


A new paper suggests that lifestyle advice for people with diabetes should be no different from that for the general public - but diabetes may benefit more from that same advice. 

In the study, the researchers investigated whether the associations between lifestyle factors and mortality risk differ between individuals with and without diabetes.


Grey literature in medicine has some valuable insight, according to a new paper. The authors say that clinical trial outcomes are more complete in unpublished reports than in publicly available information.

The results found that publicly available information contained less information about both the benefits and potential harms of an intervention than unpublished data. These findings highlight the importance of recent initiatives, such as the AllTrials initiative, that aim to make clinical trial outcome data publicly available, in order to provide complete and transparent information to help patients and clinicians reach decisions about clinical care.