Clinical Research

Grey literature in medicine has some valuable insight, according to a new paper. The authors say that clinical trial outcomes are more complete in unpublished reports than in publicly available information.

The results found that publicly available information contained less information about both the benefits and potential harms of an intervention than unpublished data. These findings highlight the importance of recent initiatives, such as the AllTrials initiative, that aim to make clinical trial outcome data publicly available, in order to provide complete and transparent information to help patients and clinicians reach decisions about clinical care.

A study to see whether narrowing of the veins from the brain to the heart could be a cause of multiple sclerosis has found that the condition is just as prevalent in people without the disease.

The results call into question a controversial theory that MS is associated with a disorder proponents call chronic cerebrospinal venous insufficiency (CCSVI).

A new paper details how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics, the mechanistic basis for how the MRSA bacterium became such a difficult pathogen over the previous 50 years, in which time it spread rapidly across the world.

MRSA has been a difficult hospital pathogen to control and has emerged in the broader community in the past several years, especially in such places as prisons, locker rooms and nurseries. In the United States alone, the disease infects about 100,000 people and claims the lives of nearly 20,000 people annually.

The first Phase II study to investigate the use of the anti-cancer drug, everolimus, for the initial treatment of advanced papillary kidney cancer has shown that it is successful in slowing or preventing the spread of the disease, according to research to be presented today (Sunday) at the 2013 European Cancer Congress (ECC2013) [1].

Working with cells in vitro and in mice, researchers have discovered that an antioxidant called ethoxyquin, a chemical commonly used as a dog food preservative, may prevent the kind of painful nerve damage found in the hands and feet of four out of five cancer patients taking the chemotherapy drug Taxol.

Ethoxyquin is a Food and Drug Administration-approved preservative and was shown in the new experiments to bind to certain cell proteins in a way that limits their exposure to the damaging effects of Taxol, the researchers say.

A multi-center study has determined that wearing back braces would prevent the need for spinal correction surgery in children with adolescent idiopathic scoliosis (AIS) - early results were overwhelmingly in favor of bracing.

Mosquitoes may seem like just a nuisance but they are more deadly to humans than any other animal. The Anopheles mosquito, for example, transmits malaria.

Researchers are on the path to using  substances that occur naturally on human skin and block mosquitoes' ability to smell and target their victims
in order to grant people, pets and livestock an 'invisibility cloak' against these blood-sucking insects.

Decitabine, a drug used to treat blood cancers, may also stop the spread of invasive breast cancer. according to a study done in lab and animal models. Decitabine turns on a gene coding for protein kinase D1 (PRKD1) that halts the ability of cancer cells to separate from a tumor and spread to distant organs.

People with Crohn’s disease, an immune disorder causing inflammation mainly in the intestines, have been forced to learn how to manage and understand their “gut.”

This, together with the chronicity of the disease and the pretty serious medications often required, means sufferers are usually very open-minded about new approaches to relieve debilitating symptoms. While the exact cause of Crohn’s is unknown, researchers believe there is a link to the “hygiene hypothesis,” the notion that there is an increase in autoimmune disease incidence rates related to clean, modern Western society.