Immunology

A biological marker in the immune system predicts our ability to fight off the common cold, starting at about age 22, according to a recent paper in JAMA


Bacteria didn't just impact our evolution, we impacted the evolution of bacteria also, according to a study of DNA preserved in calcified bacteria on the teeth of ancient human skeletons.

The ancient genetic record reveals the negative changes in oral bacteria brought about by the dietary shifts as humans became farmers, and later with the introduction of food manufacturing in the Industrial Revolution.


RNL BIO CO LTD has announced the filing of an Investigational New Drug (IND) application with the Korean Food and Drug Administration (KFDA) to initiate clinical trials phase II and III assessing the company's RNL-Astrostem(TM) stem cell drug in patients with cerebral palsy.

Cerebral Palsy is caused by non-progressive brain damage from single or multiple defect(s) on the nerve/muscular system and results in disorder in motion and sensory integration. According to Health Insurance Review and Assessment Service, the prevalence of cerebral palsy is 3.5 per 1000 male to 2.8 per 1000 female children, averaged at 3.2 per 1000 children, which is expected to increase due to reduction of premature death.




Adding fruits and vegetables to diets may help protect the kidneys of patients with chronic kidney disease (CKD) with too much acid build-up, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). This is good news, since it has also been shown that frequent dialysis poses risks for kidney patients.


Compared with standard dialysis, frequent  hemodialysis,  requires accessing the blood more often than conventional hemodialysis, can cause complications related to repeated access to the blood, requiring patients to undergo more repair procedures to the site through which blood is removed and returned, according to a study in the Journal of the American Society of Nephrology (JASN). 


Here is a conundrum in the culture wars; genetically modified tobacco has been shown to have numerous beneficial effects and now another one has been added.

The treatment for rabies (painful shots, thankfully not all in the stomach in 2013) is not as bad as the disease (death) but it is hardly civilized, so here is hoping the anti-science crowd does not claim genetically modified tobacco will create giant rats with SuperRabies.  Rabies deaths are not a big issue in the USA, 10 a year or so, and therefore it may be safe to do fundraising campaigns about Frankentobacco here, but for developing nations a better solution would save a lot of lives. 


Why has less than half of the USA gotten a flu shot, when 41 states have reported widespread, severe outbreaks of the flu?

Some of the reason is availability. They aren't going to make any more, either. Another culprit is a growing anti-vaccine movement, typified in coastal California's whooping cough outbreaks.

It's not an awareness issue. Despite widespread knowledge that a vaccine is the best way to reduce the chances of catching and spreading the flu, three of the four main NBC TODAY morning show anchors recently admitted they had not gotten a flu shot - then they did so live on the air.


It's not as fun as the Martini Diet but more scientific than the Tapeworm Diet.

A new paper says that parasitic worm infections, a major cause of disease and disability throughout much of the developing world, might actually help treat metabolic disorders associated with obesity.   

A study in Nature Medicine shows that, once inside a host, many parasitic worms secrete a sugar-based anti-inflammatory molecule that might actually help treat metabolic disorders associated with obesity. The sugar molecule - glycan - is released by parasites to help them evade the body's immune system. By reducing inflammation, they are better able to hide in tissues, and humans experience fewer symptoms that might reveal their presence.


Researchers have identified four new regions on the human genome associated with Behcet's disease, a painful and potentially dangerous condition which
causes inflammation of blood vessels in various parts of the body
- the work was aided because the disease is found predominantly in people with ancestors along the Silk Road.

Named for the Turkish physician who described it in 1937, Behcet's disease has no specific genetic or environmental cause but common symptoms include painful mouth and genital sores, and eye inflammation that can lead to blindness. In some cases, it can affect blood vessels in the brain, lungs, and other vital organs. 


Researchers have identified a mechanism by which the bacterium Staphylococcus aureus (S. aureus) colonizes our nasal passages, showing for the first time that a protein located on the bacterial surface called clumping factor B (ClfB) has high affinity for the skin protein loricrin.