Neuroscience

A new study of newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE) - a condition that occurs when the brain is deprived of an adequate oxygen supply - confirms its neuroprotective effects on the brain.

Therapeutic hypothermia or targeted cooling of the brain is the first therapy for neuroprotection in neonates with HIE. Without treatment, these babies often develop cerebral palsy or other severe complications. World-wide, nearly one million babies will die and another million will be left with disabilities.

Antipsychotic drugs are initiated in patients with Alzheimer's disease (AD) more frequently than in the general population - already 2-3 years before the Alzheimer's diagnosis, according to a new study from the University of Eastern Finland. Most commonly, antipsychotics were initiated during the six months following the Alzheimer's diagnosis; however, the incidence of new antipsychotic users was high also later on. 

Washington, DC--When a pregnant woman has gestational diabetes, her unborn child tends to react more slowly to sounds after the mother consumes sugary foods or drinks compared to the offspring of a woman who does not have the condition, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology&Metabolism.

A pair of neurons that cause males to remember and seek sex even at the expense of food. These neurons, which are male-specific, are required for sex-based differences in learning, suggesting that sex differences in cognitive abilities can be genetically hardwired. 

The study by UCL (UK) and Albert Einstein College of Medicine (USA), published today in Nature and funded by the Wellcome Trust, NIH, Marie Curie, and the G. Harold&Leila Y. Mathers Charitable Foundation, shows a direct link between contrasting behavior of male and female worms and differences in brain development and structure in areas involved in higher order processing.  

The cognitive skills used to learn how to ride a bike may be the key to a more accurate understanding of developmental dyslexia. And, they may lead to improved interventions.

Carnegie Mellon University scientists investigated how procedural learning - how we acquire skills and habits such as riding a bike - impacts how individuals with dyslexia learn speech sound categories. Published in Cortex, Lori Holt and Yafit Gabay found for the first time that learning complex auditory categories through procedural learning is impaired in dyslexia. This means that difficulty processing speech may be an effect of dyslexia, not its cause.

How did the world sound to our ancient human relatives two million years ago?

While we obviously don’t have any sound recordings or written records from anywhere near that long ago, we do have one clue: the fossilized bones from inside their ears. The internal anatomy of the ear influences its hearing abilities.

Researchhas linked the abnormal behavior of two genes (BDNF and DTNBP1) to the underlying cause of schizophrenia. These findings have provided a new target for schizophrenia treatment.

Schizophrenia is a devastating mental disorder that affects nearly 1% of the total human population. The dominant cause of the disorder lies in impaired brain development that eventually leads to imbalanced signals within the brain. This imbalance within the brain is thought to cause hallucinations and paranoia in people with schizophrenia.

Neural stem cells generate new neurons throughout life in the mammalian brain. However, with advancing age the potential for regeneration in the brain dramatically declines. Scientists from the University of Zurich now identified a novel mechanism of how neural stem cells stay relatively free of aging-induced damage.

A diffusion barrier regulates the sorting of damaged proteins during cell division.

Researchers are saying a new analysis of data on the genetics of autism spectrum disorder disputes a commonly held belief that autism results from the chance combinations of commonly occurring gene mutations, which are otherwise harmless. 

They find, instead, further evidence to suggest that devastating "ultra-rare" mutations of genes that they classify as "vulnerable" play a causal role in roughly half of all autism spectrum disorder cases. The vulnerable genes to which they refer harbor what they call an LGD, or likely gene-disruption. These LGD mutations can occur "spontaneously" between generations, and when that happens they are found in the affected child but not found in either parent. 

Scientists at Karolinska Institutet and Karolinska University Hospital in Sweden have discovered a new explanation for severe early infant epilepsy. Mutations in the gene encoding the protein KCC2 can cause the disease, hereby confirming an earlier theory. The findings are being published in the journal Nature Communications.