Nothing says weight loss like botulism.
Obesity is a growing problem across the globe. Being overweight can lead to severe diseases and conditions, like diabetes and heart problems. The World Health Organization estimates that obesity is responsible for 2 to 8 percent of health care costs and 10 to 13 percent of deaths in various parts of Europe.
Research from the Norwegian University of Science and Technology has had promising experimental results using Botox, commonly known for transforming the faces of Bruce Jenner and Joan Rivers into plastic masks, as a weight loss tool in rats. Helene Johannessen, a Ph.D. candidate at NTNU, is studying whether or not Botox could be used as an alternative to treating morbid obesity, replacing costly and dangerous operations.
Helene Johannessen, a PhD candidate at the Norwegian University of Science and Technology. Credit: NTNU
Tests on rats have shown that treatments with Botox injected into the vagus nerve in the stomach can lead to weight loss. When Johannessen injected rats with Botox, the animals ate less and lost 20-30 per cent of their body weight over five weeks. The treatment effectively paralyzes the vagus nerve, which triggers the sense of hunger and controls the passing of food through the intestines.
Paralyzing the nerve paralyzes muscles in the stomach, which appears to slow the passage of food through the stomach. This effect might one day lead to treatments that cause people to feel fuller for longer.
The hope is that the use of botox can be developed into an alternative to gastric bypass surgery. Johannessen and her research are part of the Experimental Surgery and Pharmacology research group, which is exploring alternatives to gastric surgery. The Botox treatment study is part of an EU project called Full4Health.
Botox is actually botulinum toxin, which when ingested in spoiled foods can lead to both paralysis and death. Nowadays Botox is used in the medical treatment of dystonias and spasms, as well for its more famous cosmetic use. If Johannessen and her colleagues succeed in their efforts, it might also become useful in giving people a healthier and less weighty life.
Johannessen told the Norwegian Broadcasting Corporation (NRK) that her research team will start human clinical studies as soon as Norwegian medical ethics authorities give their approval. “As a start, we will be inviting patients who are candidates for obesity operations but who, for one reason or another, cannot undergo one.”
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Asian Peat Fire Impact On Climate Change
- CohBar Completes IPO To Develop Mitochondrial-Derived Therapeutics
- The Plot Of The Week: CMS Search For Majorana Neutrinos
- Football Physics: The Science Of Deflategate
- Protein Kinase C Enzymes Believed To Promote Cancer Actually Suppress It
- We're Playing Classical Music All Wrong
- Think Mosquitoes Bite You More Than Other People? Here's Why You May Be Right
- "Your article makes no sense! What if the pats heat their footballs up to 120 degrees before the..."
- "Thanks as usual for the update. A small typo: annichilate in the third paragraph. And a question..."
- "Error bars are the responsible thing to do. I don't see an aesthetic problem. Nice pix last week..."
- "I think a smaller market means a lot higher quality. We get so many terrible pop songs because..."
- "The air inside a leather football is not an ideal gas. That is what I meant.As far as the..."
- Sociologists discover young women and men prefer egalitarian relationships
- Citizen scientists have positive news for Puget Sound seabirds
- Sleeping on stomach increases risk of sudden death in epilepsy
- BPA exposure during pregnancy correlated to oxidative stress in child, mother
- Ventricular assist devices induce heart muscle regeneration