Researchers say they have found another potential risk factor for breast cancer--Grandma's diet.
Georgetown University scientists say that pregnant rats that ate a high fat diet not only increased breast cancer risk in their female daughters but also in that daughter's offspring – the "granddaughters." Details of the study will be presented at the AACR Annual Meeting 2010.
Why the risk is passed on through two generations is unknown, but experts believe it occurs through as-yet unknown "epigenetic" changes that result in an increase in terminal end buds in the breast tissue – an increase that apparently can then be passed on through generations.
These buds are believed to be the structures where breast cancer can develop, and having more of these structures seems to increase breast cancer risk, says the study's lead investigator, Sonia de Assis, Ph.D., a postdoctoral fellow in Leena Hilakivi-Clarke's laboratory at Lombardi. "That is our theory, but we really don't know how it is happening – just yet."
The researchers add that while the grandmother ate a diet that was 43 percent fat, she didn't eat more calories than a control population of rats, and both her daughters and granddaughters ate a normal chow.
The risk appears to not only extend from mother to daughter and granddaughter, but also from mother to son to granddaughter. For example, the daughters of male and female rats born from mother rats that ate a lot of fat had an 80 percent chance of developing breast cancer, but the risk was about 69 percent if the granddaughter's mother or father was born from a rat that ate normally and the other parent came from a high-fat-consuming parent. By contrast, granddaughters of grandmother rats who ate a normal chow had a 50 percent chance of developing breast cancer.
They also studied a different control populations of rats given estradiol- a form of estrogen – and saw no increase in breast cancer risk in granddaughters. That suggests that the increased estrogen production related to eating more fat is not the source of the problem, they say.
"The implications from this study are that pregnant mothers need to eat a well balanced diet because they may be affecting the future health of their daughters and granddaughters," says de Assis.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- 3X Saturated Fat In The Diet Doesn't Increase It In Blood
- Eosinophilic Esophagitis: Genetic Clues Of Severe Food Allergy
- Still No Contact with NASA's Sun-watching Probe
- Interstellar Is A Dangerous Fantasy Of US Colonialism
- Want A Man To Help? High Heels Work
- Is Religion A Consolation Worth Having?
- "As an earlier cigarette smoker and now e-cig smoker, I can confirm they don't help you quit. As..."
- "Reality? What is reality if you use irrational arguments to justify man's cruelty toward..."
- "Always loved the Heels that showed of the instep (arches) ..."
- "By the way, I am a fan of your blog. It's one of the few places I can follow physics without getting..."
- "Hello Anon,you're entirely right, it's arbitrary and it does not provide protection against cases..."
- Gene in kidney may play role in high blood pressure
- Panel-based genetic diagnostic testing for inherited eye disease proves highly accurate
- Research finds tooth enamel fast-track in humans
- Good news for cocaine users: Caffeine counters cocaine's effects on women's estrus cycles
- Clipping proteins that package genes may limit abnormal cell growth in tumors
Books By Writers Here