Researchers say they have found another potential risk factor for breast cancer--Grandma's diet.
Georgetown University scientists say that pregnant rats that ate a high fat diet not only increased breast cancer risk in their female daughters but also in that daughter's offspring – the "granddaughters." Details of the study will be presented at the AACR Annual Meeting 2010.
Why the risk is passed on through two generations is unknown, but experts believe it occurs through as-yet unknown "epigenetic" changes that result in an increase in terminal end buds in the breast tissue – an increase that apparently can then be passed on through generations.
These buds are believed to be the structures where breast cancer can develop, and having more of these structures seems to increase breast cancer risk, says the study's lead investigator, Sonia de Assis, Ph.D., a postdoctoral fellow in Leena Hilakivi-Clarke's laboratory at Lombardi. "That is our theory, but we really don't know how it is happening – just yet."
The researchers add that while the grandmother ate a diet that was 43 percent fat, she didn't eat more calories than a control population of rats, and both her daughters and granddaughters ate a normal chow.
The risk appears to not only extend from mother to daughter and granddaughter, but also from mother to son to granddaughter. For example, the daughters of male and female rats born from mother rats that ate a lot of fat had an 80 percent chance of developing breast cancer, but the risk was about 69 percent if the granddaughter's mother or father was born from a rat that ate normally and the other parent came from a high-fat-consuming parent. By contrast, granddaughters of grandmother rats who ate a normal chow had a 50 percent chance of developing breast cancer.
They also studied a different control populations of rats given estradiol- a form of estrogen – and saw no increase in breast cancer risk in granddaughters. That suggests that the increased estrogen production related to eating more fat is not the source of the problem, they say.
"The implications from this study are that pregnant mothers need to eat a well balanced diet because they may be affecting the future health of their daughters and granddaughters," says de Assis.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Cool, Dim Dwarf Star Is Magnetic Powerhouse
- Supersymmetry Is About To Be Discovered, Kane Says
- Our Ethical Responsibilities To Baby Terraformed Worlds - Like Parents
- Thanksgiving Science 2015
- Discovery Could Open Door To Frozen Preservation Of Tissues, Whole Organs
- Secrets Of Dark Proteome
- New Gene Map Reveals Cancer's Achilles Heel
- "I know. And earlier this year other people said that the world would end on September 24th. Before..."
- "Hello Mr. Walker. I'm incredibly frightened of Nibiru and all these 'theories' surrounding it and..."
- "I am not paid to debunk Nibiru. Nor is Neil deGrasse Tyson or Brian Cox or the director of the..."
- "people are saying that this nibiru is tugging on us and it will definetly be here in December and..."
- "hi mr walker ive got a question for are u paid to debunk this nibiru or is everthing u are saying..."
- A common mechanism for human and bird sound production
- Synapse discovery could lead to new treatments for Alzheimer's disease
- Study shows white matter damage caused by 'skunk-like' cannabis
- Cognitive behavior therapy can help overcome fear of the dentist
- Don't forget plankton in climate change models, says study