End-stage renal disease, or chronic kidney failure, affects more than 500,000 people per year in the United States alone and is only fully treated with a kidney transplant.
Yet there were only 17,000 donated kidneys for transplants last year and the number of patients on the transplant waiting list currently exceeds 85,000, according to the Organ Procurement and Transplant Network.
350,000 patients are instead reliant on kidney dialysis, which comes at a tremendous cost. The Medicare system alone spends $25 billion on treatments for kidney failure, more than 6 percent of the total budget, though the disease affects only 1 percent of Medicare recipients. That cost includes almost $75,000 per patient each year for dialysis, according to the U.S. Renal Data System. Dialysis also takes a human toll. A typical dialysis schedule is three sessions per week, for 3 to 5 hours per session, in which blood is pumped through an external circuit for filtration. This is exhausting for patients and only replaces 13 percent of kidney function and, as a result, only 35 percent of patients survive for more than 5 years.
With the limited supply of donors, that means thousands of patients die each year waiting for a kidney, but UCSF researchers today unveiled a prototype model of the first implantable artificial kidney, in a development that one day could eliminate the need for dialysis.
The device, which would include thousands of microscopic filters as well as a bioreactor to mimic the metabolic and water-balancing roles of a real kidney, is being developed in a collaborative effort by engineers, biologists and physicians nationwide, led by Shuvo Roy, PhD, in the UCSF Department of Bioengineering and Therapeutic Sciences.
The treatment has been proven to work for the sickest patients using a room-sized external model developed by a team member in Michigan. Roy's goal is to apply silicon fabrication technology, along with specially engineered compartments for live kidney cells, to shrink that large-scale technology into a device the size of a coffee cup. The device would then be implanted in the body without the need for immune suppressant medications, allowing the patient to live a more normal life.
A model of the implantable bioartificial kidney shows the two-stage system. Thousands of nanoscale filters remove toxins from the blood, while a BioCartridge of renal tubule cells mimics the metabolic and water-balance roles of the human kidney. Credit: UCSF
"This device is designed to deliver most of the health benefits of a kidney transplant, while addressing the limited number of kidney donors each year," said Roy, an associate professor in the UCSF School of Pharmacy who specializes in developing micro-electromechanical systems (MEMS) technology for biomedical applications. "This could dramatically reduce the burden of renal failure for millions of people worldwide, while also reducing one of the largest costs in U.S. healthcare."
The team has established the feasibility of an implantable model in animal models and plans to be ready for clinical trials in five to seven years.
The two-stage system uses a hemofilter to remove toxins from the blood, while applying recent advances in tissue engineering to grow renal tubule cells to provide other biological functions of a healthy kidney. The process relies on the body's blood pressure to perform filtration without needing pumps or an electrical power supply.
The project exemplifies the many efforts under way at UCSF to build collaborations across scientific disciplines that accelerate the translation of academic research into real solutions for patients, according to Mary Anne Koda-Kimble, PharmD, dean of the UCSF School of Pharmacy.
"This is a perfect example of the work we are doing at UCSF to address some of the most critical medical issues of our time, both in human and financial costs," Koda-Kimble said. "This project shows what can be accomplished by teams of scientists with diverse expertise, collaborating to profoundly and more quickly improve the lives of patients worldwide."
The creation of the Department of Bioengineering and Therapeutic Sciences – a joint department in the UCSF schools of Pharmacy and Medicine – was itself an effort to promote translational research at UCSF by forming collaborations across biomedical specialties. Roy is also a founding faculty member of the UCSF Pediatric Device Consortium, which aims to accelerate the development of innovative devices for children health, and a faculty affiliate of the California Institute for Quantitative Biosciences (QB3) at UCSF.
His team is collaborating with 10 other teams of researchers on the project, including the Cleveland Clinic where Roy initially developed the idea, Case Western Reserve University, University of Michigan, Ohio State University, and Penn State University.
The first phase of the project, which has already been completed, focused on developing the technologies required to reduce the device to a size that could fit into the body and testing the individual components in animal models. In the second and current phase, the team is doing the sophisticated work needed to scale up the device for humans. The team now has the components and a visual model and is pursuing federal and private support to bring the project to clinical use.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Sam Ting On AMS Results: Dark Matter Might Be One Seminar Away
- BICEP2's vision wasn't that strong, Planck says their window was too dusty.
- Why Natural Gas, Including Fracking, Is Better For The Environment Than Wind And Solar
- Quantum Teleportation 25 Kilometers Away
- Graphene Sensor Tracks Down Cancer Biomarkers
- Vitriolic Abuse Of Anita Sarkeesian: Why The Games Industry Needs Her
- 30 Years Left To Reach The Limit: CO2 Emissions Will Reach New Record High In 2014
- "I have been a target of a similar attack for standing up for the academic freedom of other scientist..."
- "True, but isn't it very likely that there are particles out there we know absolutely nothing about..."
- "What is sexism? Treating Anita Sarkeesian differently than Jack Thompson, solely because she's..."
- "I agree with John: Cosmos: A Spacetime Odyssey, Season 1, Episode 13, Dark Matter/Dark Energy Mysteries..."
- "Okay good point. Not suggesting we do this imminently, if we do it at all.Yes, agree, many potential..."