"My two dads" is no longer just a lousy TV show. Using induced pluripotent stem cell technology (controversy-free!) scientists have produced male and female mice from two fathers.
It isn't part of any cultural agenda, the intent was to preserve endangered species, but obviously it opens up the possibility of same-sex couples having their own genetic children. The authors caution that the "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes."
In the work reported today, the researchers manipulated fibroblasts from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line. About one percent of iPS cell colonies grown from this XY cell line spontaneously lost the Y chromosome, resulting in XO cells. The XO iPS cells were injected into blastocysts from donor female mice. The treated blastocysts were transplanted into surrogate mothers, which gave birth to female XO/XX chimeras having one X chromosome from the original male mouse fibroblast.
The female chimeras, carrying oocytes derived from the XO cells, were mated with normal male mice. Some of the offspring were male and female mice that had genetic contributions from two fathers.
According to the authors, "Our study exploits iPS cell technologies to combine the alleles from two males to generate male and female progeny, i.e. a new form of mammalian reproduction."
The technique described in this study could be applied to agriculturally important animal species to combine desirable genetic traits from two males without having to outcross to females with diverse traits.
"It is also possible that one male could produce both oocytes and sperm for self-fertilization to generate male and female progeny," the scientists point out. Such a technique could be valuable for preserving species when no females remain.
In the future, it may also be possible to generate human oocytes from male iPS cells in vitro. Used in conjunction with in vitro fertilization, this would eliminate the need for female XO/XX chimeras, although a surrogate mother would still be needed to carry the two-father pregnancy to term.
Using a variation of the iPS technique, the researchers say "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."
Citation: Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang, M. David Stewart, Hongran Wang, Austin J. Cooney, and Richard R. Behringer, 'Generation of Viable Male and Female Mice from Two Fathers', Biol Reprod doi:10.1095/biolreprod.110.088831
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Thou Shalt Have One Higgs - $100 Bet Won !
- Could Astronauts In The ISS Get All Their Oxygen & Food From Algae & Plants?
- FDA Stiffs Go Soft On Pink Viagra
- Stem Cell Research Informed Consent: What To Know
- Breast Cancer Study Misunderstood By Its Authors
- The Spread Of Life Among The Stars
- A Historical Moment For Diabetes
- "this article is not being truthful!its basically saying biblical truth is fabricated!! no one will..."
- "Bottom line is any drug with fluoride in it should be black boxed and restricted to life and death..."
- "I agree. No need to bet to enjoy the race, whatever time it takes. I do hope that the LHC experimenters..."
- "LOL! I laughed so hard at this article! This was before its time- love it. I am the Celiac who..."
- "Hi Tony,let me just say that I do hope your model is correct!!!And after all we don't need to go..."
- Goth teens more vulnerable to depression and self-harm
- 15 percent of cigarettes sold in NYC have illegal tax stamps
- Humans may be harmed by endocrine disrupting chemicals released during fracking, according to review
- Infliximab biosimilar approved in Australia - lower cost is great, but questions about safety remain
- The radiationless revolution in electromagnetics
Books By Writers Here