"My two dads" is no longer just a lousy TV show. Using induced pluripotent stem cell technology (controversy-free!) scientists have produced male and female mice from two fathers.
It isn't part of any cultural agenda, the intent was to preserve endangered species, but obviously it opens up the possibility of same-sex couples having their own genetic children. The authors caution that the "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes."
In the work reported today, the researchers manipulated fibroblasts from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line. About one percent of iPS cell colonies grown from this XY cell line spontaneously lost the Y chromosome, resulting in XO cells. The XO iPS cells were injected into blastocysts from donor female mice. The treated blastocysts were transplanted into surrogate mothers, which gave birth to female XO/XX chimeras having one X chromosome from the original male mouse fibroblast.
The female chimeras, carrying oocytes derived from the XO cells, were mated with normal male mice. Some of the offspring were male and female mice that had genetic contributions from two fathers.
According to the authors, "Our study exploits iPS cell technologies to combine the alleles from two males to generate male and female progeny, i.e. a new form of mammalian reproduction."
The technique described in this study could be applied to agriculturally important animal species to combine desirable genetic traits from two males without having to outcross to females with diverse traits.
"It is also possible that one male could produce both oocytes and sperm for self-fertilization to generate male and female progeny," the scientists point out. Such a technique could be valuable for preserving species when no females remain.
In the future, it may also be possible to generate human oocytes from male iPS cells in vitro. Used in conjunction with in vitro fertilization, this would eliminate the need for female XO/XX chimeras, although a surrogate mother would still be needed to carry the two-father pregnancy to term.
Using a variation of the iPS technique, the researchers say "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."
Citation: Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang, M. David Stewart, Hongran Wang, Austin J. Cooney, and Richard R. Behringer, 'Generation of Viable Male and Female Mice from Two Fathers', Biol Reprod doi:10.1095/biolreprod.110.088831
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Yellowstone Volcanic System Four Times Bigger Than Thought
- Columbia's Lame Oz Defense
- We Don't Hear Much About The 10,000 French Deaths At Gallipoli
- The Evolutionary Psychology Reason Some People Will Be Anti-GMO
- Pictures Of March 20th Eclipse From Svalbard
- Poison As Medicine And How Venom Can Sometimes Be A Savior
- It Shouldn't Be There: Henize 2-10 And The Cosmic Conundrum
- "Does this make any sense?Wormholes Untangle Black Hole Paradox - K.C. Cole, Quanta ..."
- "Good discussion. One would think that any sensible person could smell the snake oil even through..."
- "That is true. Matthew proposed it as a hypothesis. He actually invited naturalists to test it by..."
- "It is an absolute shame that such a brilliant doctor is being crucified in the media, although..."
- "I've got to say that I reserve some measure of awe at the P.T. Barnum gall some people have. Belle..."
- 'Time is money' thinking hurts the environment
- Cell phones distract parents watching kids on playgrounds
- Cheaters and the cheated: Biased reports on international students don't help
- Conservation win: Hawaiian Honeycreeper hatches its way back from the brink of extinction
- Despite pediatric guidelines, babies as young as 6 months using mobile media