"My two dads" is no longer just a lousy TV show. Using induced pluripotent stem cell technology (controversy-free!) scientists have produced male and female mice from two fathers.
It isn't part of any cultural agenda, the intent was to preserve endangered species, but obviously it opens up the possibility of same-sex couples having their own genetic children. The authors caution that the "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes."
In the work reported today, the researchers manipulated fibroblasts from a male (XY) mouse fetus to produce an induced pluripotent stem (iPS) cell line. About one percent of iPS cell colonies grown from this XY cell line spontaneously lost the Y chromosome, resulting in XO cells. The XO iPS cells were injected into blastocysts from donor female mice. The treated blastocysts were transplanted into surrogate mothers, which gave birth to female XO/XX chimeras having one X chromosome from the original male mouse fibroblast.
The female chimeras, carrying oocytes derived from the XO cells, were mated with normal male mice. Some of the offspring were male and female mice that had genetic contributions from two fathers.
According to the authors, "Our study exploits iPS cell technologies to combine the alleles from two males to generate male and female progeny, i.e. a new form of mammalian reproduction."
The technique described in this study could be applied to agriculturally important animal species to combine desirable genetic traits from two males without having to outcross to females with diverse traits.
"It is also possible that one male could produce both oocytes and sperm for self-fertilization to generate male and female progeny," the scientists point out. Such a technique could be valuable for preserving species when no females remain.
In the future, it may also be possible to generate human oocytes from male iPS cells in vitro. Used in conjunction with in vitro fertilization, this would eliminate the need for female XO/XX chimeras, although a surrogate mother would still be needed to carry the two-father pregnancy to term.
Using a variation of the iPS technique, the researchers say "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."
Citation: Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang, M. David Stewart, Hongran Wang, Austin J. Cooney, and Richard R. Behringer, 'Generation of Viable Male and Female Mice from Two Fathers', Biol Reprod doi:10.1095/biolreprod.110.088831
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- Part I: Bee Deaths Mystery Solved? Neonicotinoids (Neonics) May Actually Help Bee Health
- Smoking, Drinking And Eating: It's Not About Your Freedom
- Chronic Pain Isn't All In The Brain
- Part II: Bee Deaths And CCD - Flawed Chensheng Lu Harvard Studies Endanger Bees
- Violence, Sex And Taboo: The Original Brothers Grimm Fairy Tales Back In Print
- Like Collaboration And Intelligence In Humans? Thank War
- Diversity Fatigue: Why Businesses Struggle To Close The Gender Gap
- "There is no question they were created to cater to universities and are staffed by people from..."
- "And my second link should be not a copy of the first, but this: http://www.nature.com/news/half..."
- "Recently I saw The Conversation remove/censor legitimate comments arguing against an article written..."
- tags because there's no testing..." href="/robert_inventor/why_we_cant_backup_earth_on_mars_the_moon_or_anywhere_else_in_our_solar_system-148364#comment-182183">"Robert, you might want to reformat my post. I intended to highlight only the headlines for easy..."
- "My only complaint with good thinkers and writers has hither always been that they should produce..."
- Behavioral interventions to prevent progression to diabetes equally effective in men and women
- Gender differences in adaptation to space flight
- Long-term complication rate low in nose job using patient's own rib cartilage
- Survival differences seen for advanced-stage laryngeal cancer
- Effect of once-daily, low-dose aspirin on heart attack deaths and other outcomes
Books By Writers Here