Genome editing using CRISPR/Cas system has enabled direct modification of the mouse genome in fertilized mouse eggs, leading to rapid, convenient, and efficient one-step production of knockout mice without embryonic stem cells.

In contrast to the ease of targeted gene deletion, the complementary application, called targeted gene cassette insertion or knock-in, in fertilized mouse eggs by CRISPR/Cas mediated genome editing still remains a tough challenge.

To understand how transposable elements, DNA sequences capable of moving independently,  shape genomes, where they are maintained over generations, it is vital to discover the mechanisms behind their targeted integration.

Researchers from the Laboratoire Pathologie et Virologie Moléculaire (CNRS/Inserm/Université Paris Diderot), Institut de biologie intégrative de la cellule and the University of Minnesota have identified an interaction between two proteins that is essential for the integration of a transposable element into a specific area of the yeast genome. The results emphasize the role of these mobile DNA sequences in the evolution and adaptation of organisms, and their potential value for gene therapy.

A group of researchers analyzed a marine sponge called Halichondrin okadai  because they were curious why it inhibited the replication of organisms around it.

They found that a mesylate eribulin substance had been applied to patients with breast cancer patients in the stage of metastasis, when the disease spreads to other parts of the body, and that it inhibited tumor growth.

Researchers are reporting that pancreatic cancer rates are highest in countries with the least amount of sunlight, due to a combination of heavy cloud cover and high latitude. 

Researchers have developed and used a new technique to connect the dots in the genomic puzzle. Just as dots have to be connected to visualize a full picture, the researchers connected regulatory elements called promoters and enhancers and showed their physical interactions over long distances within the mouse and human genomes.

The ability to map promoter-enhancer interactions in the human genome has huge potential in understanding the genetic basis of disease.

In a study of how people interacted with avatars in World of Warcraft, women received less help from fellow players than men when they operated an unattractive avatar - even less than when they used a male avatar, according to a paper in the Journal of Broadcasting and Electronic Media.

This matches beliefs about how appearance stereotypes affect men and women in the real world. Some women believe they are more likely to suffer negative consequences based on their appearance than men are.