More than 60 percent of the world's population is infected with a type of herpes virus called human cytomegalovirus, which replicates by commandeering the host cell's metabolism, but the details of this maneuver have been unclear.

Researchers have discovered that cytomegalovirus manipulates a process called fatty acid elongation, which makes the very-long-chain fatty acids necessary for virus replication. They identified a specific human enzyme - elongase enzyme 7 - that the virus induces to turn on fatty acid elongation.

"Elongase 7 was just screaming, 'I'm important, study me,'" said John Purdy, a post-doctoral researcher at Princeton and lead author of the study. 

Cigarette smoking is down, thanks to fines and taxes on cigarette companies that fund anti-smoking campaigns - but hookah (water pipe) use is up. A new paper in Cancer Causes and Control worries that almost one in four high school seniors may try smoking hookah and 78,200 youth are current water pipe users.

Water pipes work by bubbling tobacco smoke through water, leading some users to believe that they carry less risk than cigarettes. The study, which analyzed data from the national 2012-2013 Youth Smoking Survey, found that over a third of youth believe it is less harmful to smoke tobacco in a water pipe than smoking a cigarette. 

Bisphenol A (BPA) is a chemical that is used in a variety of consumer products, such as water bottles, dental composites and resins used to line metal food and beverage containers. Often, aquatic environments such as rivers and streams become reservoirs for contaminants, which can include products containing BPA.

A new experiment was able to expose fish to endocrine-disrupting chemicals and cause them to pass adverse reproductive effects onto their offspring as many as three generations later, leading the authors to suggest that BPA could have adverse reproductive effects for fish and also humans and their offspring who are exposed to BPA as well.

Patients with carpal tunnel syndrome are more than twice as likely to have migraine headaches, reports a study in Plastic and Reconstructive Surgery--Global Open. The association also runs in the other direction, with migraine patients having higher odds of carpal tunnel syndrome.

The researchers analyzed data from nearly 26,000 Americans responding to a national health survey. Among other questions, participants were asked whether they had had carpal tunnel syndrome during the past year or "severe headache or migraine" during the past three months. Patients with carpal tunnel syndrome have symptoms such as hand numbness and weakness, resulting from pressure on the median nerve in the wrist.

Verbal abuse, aggressive behavior, criminal damage to objects are expected in certain professions but hardly anyone includes doctors, although they are exposed to such incidents - and not just in dictatorships or the developing world. 

Florian Vorderwülbecke and colleagues writing in Deutsches Ärzteblatt International (Dtsch Arztebl Int 2015; 112: 159-65) investigate how often acts of violence and aggression against primary care physicians are committed in Germany. They surveyed 1500 doctors, asking which assaults they had been exposed to, and where these took place, among other questions. 

A 3-dimensional model of human respiratory tissue has been shown to be effective for measuring the impact of chemicals, like those found in cigarette smoke or other aerosols, on the lung. 

More effective lab-based tests are required to reduce the need for animal testing in assessing the toxicological effects of inhaled chemicals and safety of medicines. Traditional lab-based tests use cell lines that do not reflect normal lung structure and physiology, and in some cases have reduced, or loss of, key metabolic processes.