Estrogen plays an important role in determining how sensitive a person is to pain, and the estrogen receptor known as ER-beta is particularly significant in this context. These are the conclusions of a study from the Swedish medical university Karolinska Institutet.

"This may mark the beginning of the production of a new class of analgesic drugs", says Professor Jan-Åke Gustafsson, Department of Biosciences and Nutrition.

Earlier studies have shown that estrogen affects how we experience pain, but the mechanisms behind this have been unclear. Estrogen can bind to two different receptors, known as ER-alpha and ER-beta, and the new study describes results obtained concerning the expression of these two receptors in the spinal cord.

Following World War II, the U.S. began increasing its commitment to publicly-funded science. The responsibility of the scientist was thought to be a straightforward process: if the scientists asked the “right” questions, their answers would help policy makers to make the “right” decisions.

However, the questions asked by researchers do not always translate easily into policy.

Which genes are passed on from mother to child is decided very early on during the maturation of the egg cell in the ovary. In a cell division process that is unique to egg cells, half of the chromosomes are eliminated from the egg before it is fertilised. Using a powerful microscope, researchers from the European Molecular Biology Laboratory (EMBL) have now revealed how the molecular machinery functions that is responsible for chromosome reduction of egg cells in mice. In the current issue of Cell they report the assembly of this machinery, which is very different from what happens in all other cells in the body. The process is likely conserved across species and the new insights might help shed light on defects occurring in human egg cell development.

Oregon Health & Science University researchers have figured out how to turn a mouse into a factory for human liver cells that can be used to test how pharmaceuticals are metabolized.

The technique could soon become the gold standard not only for examining drug metabolism in the liver, which helps scientists determine a drug's toxicity.

The space shuttle Endeavour and its seven-member crew lifted off at 6:36 p.m. EDT Wednesday from NASA's Kennedy Space Center in Florida. The astronauts are on their way to the International Space Station for an assembly mission, designated STS-118.

"This is serious business we're in here," said Endeavour's Commander Scott Kelly to the shuttle launch director shortly before lift off. "I'm proud of your team for getting Endeavour ready to go fly. I'm also proud of my crew and the rest of the astronaut office for the competence and professionalism and consistently making something that is incredibly difficult look easy."

Kelly then added, "We'll see you in a couple of weeks, and thanks for loaning us your space shuttle."

A new WWF study tracking pygmy elephants by satellite shows that the remaining herds of these endangered elephants, which live only on the island of Borneo, are under threat from forest fragmentation and loss of habitat.

Borneo pygmy elephants depend for their survival on forests situated on flat, low lands and in river valleys, the study found. Unfortunately, it is also the type of terrain preferred for commercial plantations. Over the past four decades, 40 percent of the forest cover of the Malaysian State of Sabah, on the northeast of the Island of Borneo – where most of pygmy elephants are – has been lost to logging, conversion for plantations and human settlement.