Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.

The investigators say their study is one of the first of rare genetic variations in people with bipolar disorder, which, in contrast to most previous studies of common variation, can provide a more direct insight into the biology underlying the susceptibility to bipolar disorder.

Authors from Lake Erie Research Institute in Pennsylvania report an adjustable foot wrap caused to treat restless legs syndrome (RLS) is 1.4 times more effective than the standard pharmaceutical treatment. The pilot study published today in The Journal of the American Osteopathic Association.

The eight-week clinical trial involved 30 otherwise healthy adults with moderate to severe restless leg syndrome. Researchers studied Clinical Global Impression responses as well as the mean change in the International Restless Leg Syndrome Study Group Study Scale (IRLSSGS). A meta-analysis was then used to compare the RLS device with three historic studies of the medication ropinirole and a placebo.

Beijing and surrounding areas of China often suffer from choking smog. The Chinese government has made commitments to improving air quality and has achieved notable results in reducing emissions from the power and transportation sectors. However, new research indicates that the government could achieve dramatic air quality improvements with more attention on an overlooked source of outdoor pollution -- residential cooking and heating.

TORONTO, June 27, 2016 - Handheld, mobile phone-based microscopes can be used in developing countries after minimal training of community laboratory technicians to diagnose intestinal parasites quickly and accurately.

Perovskite is a material with an almost ideal structure. The majority of high-temperature superconductors are perovskite-based due to their non-ideal structure. The material can also be used to produce flexible solar batteries without rare-earth metals, which would help to reduce costs and enable large-scale manufacture.

Researchers at Johns Hopkins have found that an old drug once mostly used to treat amebiasis -- a disease caused by a parasite -- and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus that can cause serious disease in immunocompromised individuals, including those with HIV or organ transplant recipients.

A report on the finding, made in test tube and mice studies, is published in the June 23 PLOS Pathogens and could potentially offer a much-needed tool to inhibit CMV, the investigators say.