A data-driven computational approach developed by a University of Illinois statistician is revealing secrets about inner Earth and discovering unique gene expressions in fruit flies, zebra fish and other living organisms.

"Using mathematical concepts from inverse scattering and modern statistics, we let the data 'speak,' and automatically generate an appropriate model," said Ping Ma, a professor of statistics at the U. of I. and lead author of a paper describing the technique that has been accepted for publication in the Journal of Geophysical Research.

You may not be able to relive your youth, but part of your brain can. Johns Hopkins researchers have found that newly made nerves in an adult brain's learning center experience a one-month period when they are just as active as the nerves in a developing child. The study, appearing this week in Neuron, suggests that new adult nerves have a deeper role than simply replacing dead ones.

Shire plc announced today the positive results of studies of the investigational medication guanfacine extended release (GXR, previously referred to as SPD503), a selective alpha-2A-adrenoceptor agonist. These data from two short-term phase III placebo-controlled studies and two long-term phase III open-label studies, presented at the 2007 American Psychiatric Association (APA) annual meeting, demonstrated that GXR significantly improved all core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 17 years.

Shire plc announced that DAYTRANATM (methylphenidate transdermal system), the first and only non-oral medication approved for treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6 to 12 years, provided significant improvement in symptom control and tolerability, according to results of a 12-month open-label study presented at the American Psychiatric Association (APA) annual meeting in San Diego.

Findings presented today at Digestive Disease Week® 2007 (DDW), from long-term extensions of the ACT trials (Active Ulcerative Colitis 1 & 2) show that subjects with moderately to severely active ulcerative colitis (UC) who had responded to REMICADE® (infliximab) in the blinded phase of the trials maintained improvement in their clinical symptoms for up to two years.

New evidence indicates that small pieces of noncoding genetic material known as microRNAs (miRNAs) might influence cancer susceptibility. Differences in certain miRNAs may predispose some individuals to develop cancer, say researchers.

MiRNAs play a number of roles in biological regulation, including development and cell differentiation, helping to determine what type a cell ultimately becomes. But when damaged, they can contribute to cancer by either turning on cancer-causing genes or by inhibiting tumor-blocking genes. The ways that MiRNAs are expressed have been used to profile tumor types in humans.