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More than half (53 percent) of U.S. consumers want to know what’s in their DNA, according to a new survey, yet only 7 percent of respondents say that their doctor has discussed genetic screening with them.

The nationwide survey, conducted by marketing research company ORC International among a representative sample of 1,020 adults, explored knowledge of and attitudes toward genetic testing among adult consumers. The strong interest in genetic screening that is evident from the survey can be attributed to a variety of factors, but may point to an interest among consumers in using genetic screening to be more proactive about their healthcare.

When cells from the connective tissue collide, they repel one another - this phenomenon was discovered more than 50 years ago. It is only now, however, that researchers at the University of Basel have discovered the molecular basis for this process, as they report in the journal Developmental Cell. Their findings could have important implications for cancer research.

Fibroblasts are motile constituents of the connective tissue and also regulate its stiffness. Moreover, fibroblasts play an important role in malignant skin diseases such as melanoma. In research, they serve as a model system for studying cell migration.


Signaling pathway identified


Everyone knows that exercise improves health, and ongoing research continues to uncover increasingly detailed information on its benefits for metabolism, circulation, and improved functioning of organs such as the heart, brain, and liver. With this knowledge in hand, scientists may be better equipped to develop "exercise pills" that could mimic at least some of the beneficial effects of physical exercise on the body.

A review of current development efforts in Trends in Pharmacological Sciences, ponders whether such pills will achieve their potential therapeutic impact, at least in the near future.

Glioblastoma is an aggressive brain cancer that kills two-thirds of patients within five years. A patient's outlook with recurrence of the disease is considered to be weeks or months.

An experimental gene therapy essentially doubled the overall survival of patients with recurrent glioblastoma compared to the current standard of care, a researcher said October 1st at the Cancer Therapy&Research Center (CTRC) at The University of Texas Health Science Center at San Antonio. 

Strategic voting is an important factor in Canadian electoral campaigns. "People vote strategically when they think neither their first nor their second choice has any chance of winning in their electorate. They vote for their third choice party in the hopes of blocking an outcome that would be even worse," said Jean-François Daoust, a researcher at the University of Montreal's Department of Political Science who studied the phenomenon as part of his doctoral work. He was directed by André Blais, who holds the university's Research Chair for Electoral Studies, and his findings, which drew on Quebec's 2012 provincial elections, were recently published in Politiques et sociétés.

Humans have been breeding crops until they're bigger and more nutritious since the early days of agriculture, but genetic manipulation isn't the only way to give plants a boost. In a review paper, two integrative biologists present how it is possible to engineer the plant soil microbiome to improve plant growth, even if the plants are genetically identical and cannot evolve. 

These artificially selected microbiomes, which can also be selected in animals, can then be passed on from parents to offspring.