Biochemists at the national meeting of the American Chemical Society have described how proteins in alligator blood may provide a source of powerful new antibiotics to help fight infections associated with diabetic ulcers, severe burns, and “superbugs” that are resistant to conventional medication.

Previous studies by Merchant showed that alligators have an unusually strong immune system that is very different from that of humans. Unlike people, alligators can fight microorganisms such as fungi, viruses, and bacteria without having prior exposure to them. Scientists believe that this is an evolutionary adaptation to promote quick wound healing, as alligators are often injured during fierce territorial battles.

Their study found a range of other promising uses for the gator’s antibiotic proteins, including combating Candida albicans yeast infections, which are a serious problem in AIDS patients and transplant recipients, who have weakened immune systems, the scientists say.

Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting, in a study by physiologists at the Human Performance Laboratory, Ball State University.

Dr. Chad Carroll, a postdoctoral fellow working with Dr. Todd Trappe, reported study results at Experimental Biology 2008 in San Diego on April 6. His presentation was part of the scientific program of the American Physiological Society (APS).

Thirty-six men and women, between 60 and 78 years of age (average age 65), were randomly assigned to daily dosages of either ibuprofen (such as that in Advil), acetaminophen (such as that in Tylenol), or a placebo. The dosages were identical to those recommended by the manufacturers and were selected to most closely mimic what chronic users of these medicines were likely to be taking. Neither the volunteers nor the scientists knew who was receiving which treatment until the end of the study.

There is a widely held belief that maintaining a normal weight automatically guards against disorders such as high levels of circulating blood fats and a tendency to develop type 2 diabetes. More than half of American adults considered to have normal body weight have high body fat percentages -- greater than 20 percent for men and 30 percent for women -- as well as heart and metabolic disturbances, new Mayo Clinic research shows.

The researchers defined “normal weight” by body mass index (BMI). They found that people with normal BMI who had the highest percentage of body fat were also those who had metabolic disturbances linked to heart disease.

The researchers use the phrase “normal weight obesity” to describe this new type of patient at risk for metabolism problems and risk factors for heart disease, but who rates as “normal” on standard weight charts. They defined normal weight obesity as a condition of having a normal BMI with high body fat percentage.

Parkinson’s disease affects daily tasks that people take for granted. Brushing teeth, getting out of bed and walking become a problem for these patients because of dopamine depletion, which results in stiffness or slowing of movement and fine motor dysfunction.

While occupational therapy is frequently used in the comprehensive care of Parkinson’s patients, evidence is needed to support its short- or long-term effectiveness, says says Dr.

Who knew you could cure disease by getting down in the mud?

Scientists in Arizona report that minerals from clay could form the basis of a new generation of inexpensive, highly-effective antimicrobials for fighting MRSA infections that are moving out of health care settings and into the community. These “superbugs” are increasingly resistant to multiple antibiotics and cause thousands of deaths each year.

Unlike conventional antibiotics that are often administered by injection or pills, the so-called “healing clays” could be used as rub-on creams or ointments to keep MRSA infections from spreading, the researchers say. The clays also show promise against a wide range of other harmful bacteria, including those that cause skin infections and food poisoning, the scientists add. Their study, one of the first to explore the antimicrobial activity of natural clays in detail, was presented today at the 235th national meeting of the American Chemical Society.

People affected by Huntington’s disease, which affects up to one person in every 10,000 but clusters in families and certain populations, develop clusters of a defective protein in their neurons and shrinkage of brain areas associated with movement. The disorder causes disability and eventually death, but does not normally manifest until after people have had children, allowing the disease gene to be passed on.

“Although Huntington’s disease is considered the epitome of genetic determinism, environmental factors are increasingly recognised to influence the disease progress”, the researchers write.