Researchers using functional MRI (fMRI) have determined that the circuitry in the area of the brain responsible for suppressing memory is dysfunctional in patients suffering from stress-related psychiatric disorders. Results of the study will be presented today at the annual meeting of the Radiological Society of North America (RSNA).
"For patients with major depression and other stress-related disorders, traumatic memories are a source of anxiety," said Nivedita Agarwal, M.D., radiology resident at the University of Udine in Italy, where the study is being conducted, and research fellow at the Brain Imaging Center of McLean Hospital, Department of Psychiatry at Harvard Medical School in Boston. "Because traumatic memories are not adequately suppressed by the brain, they continue to interfere with the patient's life."
Dr. Agarwal and colleagues used brain fMRI to explore alterations in the neural circuitry that links the prefrontal cortex to the hippocampus, while study participants performed a memory task. Participants included 11 patients with major depression, 13 with generalized anxiety disorder, nine with panic attack disorders, five with borderline personality disorder and 21 healthy individuals. All patients reported suffering varying degrees of stressful traumatic events, such as sexual or physical abuse, difficult relationships or "mobbing" – a type of bullying or harassment – at some point in their lives.
After reviewing a list of neutral word pairs, each participant underwent fMRI. During imaging, they were presented with one of the words and asked to either recall or to suppress the memory of its associated word. The fMRI images revealed that the prefrontal cortex, which controls the suppression and retrieval of memories processed by the hippocampus, showed abnormal activation in the patients with stress-related disorders compared to the healthy controls. During the memory suppression phase of the test, patients with stress-related disorders showed greater activation in the hippocampus, suggesting that insufficient activation of the prefrontal cortex could be the basis for inadequate suppression of unwanted traumatic memories stored in the hippocampus.
"These data suggest that the mechanism for memory suppression is dysfunctional in patients with stress-related disorders primarily because of an alteration of the prefrontal cortex," Dr. Agarwal said. "These patients often complain of poor memory, which might in part be attributed to this altered circuitry," she added. According to Agarwal, fMRI is an important tool in understanding the neurobiological basis of psychiatric disorders and in identifying imaging markers to psychiatric disease, helping clinicians target specific parts of the brain for treatment.
- PHYSICAL SCIENCES
- EARTH SCIENCES
- LIFE SCIENCES
- SOCIAL SCIENCES
Subscribe to the newsletter
Stay in touch with the scientific world!
Know Science And Want To Write?
- A 3 TeV Dielectron Event By CMS !
- Germany Versus Science, Round Two
- The Dynamical Origin Of Quantum Mechanics (I)
- Mountain Doomed: CO2 Bubbles And Heart Attacks
- Bt Spray In The Organic Movement: Hypocrisy Or Scientific Illiteracy?
- Copters, Drones - Location Data Is Changing The World
- Neuron Responsible For Alcoholism Found
- "They're just examples kneemo, they probably took 3 TeV as a benchmark just because it's a bit beyond..."
- "2.9 TeV would be in agreement with Z' (SSM) fits I've seen...."
- "Your conclusion that you likely to ingest more bt toxin from organic corn in which bt can be washed..."
- "Happy blogging mr Vig power capsule..."
- "My two ICNFP 2014 contributions have been published at the addresses:http://www.epj-conferences..."
- DC’s Needle Exchange: Infections Down, Savings Up
- Are You An Old Soul? You May Just Have An Old Heart
- Prescribing Caution with Precautionary Principle
- FDA’s Welcome Action: Caffeine Is a Drug
- Over Bt Spraying, Anti-GMO Folks Undone by Own Argument
- E-Cigarettes Are Safer Than Smoking – But Aldehydes Need To Go