One way to alleviate the pain of banging your shin while on a hike is to encounter a grizzly bear—a well-known phenomenon called stress-induced analgesia. Now, researchers have elucidated a key mechanism by which the stress hormone noradrenaline — which floods the bloodstream during grizzly encounters and other stressful events — affects the brain’s pain-processing pathway to produce such analgesia.
Pankaj Sah and colleagues published their findings in the December 6, 2007, issue of the journal Neuron, published by Cell Press.
In an accompanying perspective article on the research, Harvard Medical School researchers Keith Tully, Yan Li, and Vadim Bolshakov wrote that “The impressive new study… provides important mechanistic clues helping to explain this phenomenon.”