The problem of microbial resistance is growing and the outlook for the use of antimicrobial drugs in the future is still uncertain. This problem can be reduced by controlling the use of antibiotic, develop research to better understand the genetic mechanisms of resistance, and to continue studies to develop new drugs, either synthetic or natural. The ultimate goal is to offer appropriate and efficient antimicrobial drugs to the patient. From centuries, plants have been a valuable source of natural products for maintaining human health (Kapoor, 1990). Many plants have been used because of their antimicrobial traits, which are due to compounds synthesized in the secondary metabolism of the plant. The use of plant extracts and phytochemical, both with known antimicrobial properties can be of great significance in therapeutic treatments. In the last few years, a number of studies have been conducted in different countries to prove such efficiency and many plants have been claimed for their exciting anti-microbial activity, includes: Tagetes minuta (Tereschuck et al., 1997), Euphorbia tirucalli (Lirio et al., 1998), Euphorbia poissoni (Ajali et, al., 2002), Acacia mearnsii (Smith et al., 2003), Ximenia americana (Omar and Elnima, 2003), Euphorbia nivulia Linn (Annapurna et, al., 2004) Pinus densiflora (Kim and Shin, 2005), Acacia auriculiformis (Mandal et al., 2005), Cistus villosus L., Cistus monspeliensis L. (Bouamama et al., 2006), Ageratum conyzoides (Sharma and Kumar, 2006), and Combretum imberbe (Angeh et al., 2007) etc.