Cell membrane composed of lipids is impermeable to glucose which is a polar compound. Transport of glucose across the cell membrane requires a carrier protein located in cell membrane. In plant system it is triose phosphate which is transported across the chloroplast . Availability or lack of Pi determines the transport of metabolites across chloroplast besides other factors. Cell membrane also has Na anti-porters. ATPase have some important role to play in it. Recently I came across a review in nature ( Chao and Henry (2010: Nature review Drug discovery Nature.com/nrd/collections/type2diabetes pp 30 which describes SGLT2 mediated reabsorption in the kidney. Sodium –glucose co –transporter 2 (SGLT2) catalyses active transport of glucose (against a concentration gradient ) across the luminal membrane by coupling it with the downhill transport of Na +., Earlier Sopory from ICGEB has reported role of Glyoxylase I in salinity tolerance . I was wondering in what way basic mechanisms of plants and animals are related to each other . Do we require a better understanding for sodium resistance in glucose transport systems in plants .